The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer | |
Li, Hong1,3; Wang, Huogang1,3; Deng, Ke1,3; Han, Wei2; Hong, Bo1,2,3; Lin, Wenchu1,3 | |
刊名 | CANCER BIOMARKERS |
2019 | |
卷号 | 24期号:1页码:51-59 |
关键词 | Small cell lung cancer Bcl-2 Bim ABT-263 cisplatin radiation |
ISSN号 | 1574-0153 |
DOI | 10.3233/CBM-181692 |
英文摘要 | BACKGROUND: Cisplatin-based chemotherapy and radiotherapy are the most commonly used treatments for small cell lung cancer (SCLC). However, despise initially dramatic response, the response duration of SCLC patients is variable and resistance to chemo- and radio-therapy inevitably develops. OBJECTIVE: The aim of the study is to investigate the role of Bcl-2 family proteins in predicting SCLC sensitivity to cisplatin treatment, and to identify the potential sensitizer of cisplatin or ratiation treatment in SCLC. METHODS: We collected cisplatin sensitivity data from public available database, and evaluated its possible association with mRNA or protein expression of Bcl-2 family members in SCLC cell lines. RESULTS: The IC50 value of cisplatin was significantly correlated with the ratio of Bcl-2/Bim mRNA expression in 33 SCLC cell lines (P = 0.041) as well as the ratio of Bcl-2/Bim protein expression in 7 SCLC cell lines (P = 0.0252). Furthermore, a BH3-mimetic ABT-263 was found to be able to sensitize SCLC cells to cisplatin or radiation. The synergistic and additive antitumor activity of ABT-263 combined with cisplatin or radiation was associated with the enhanced apoptosis, which may be caused by the disruption of Bcl-2 binding to Bim by ABT-263. CONCLUSIONS: Our study indicates that the ratio of Bcl-2/Bim could be a SCLC response predictor to cisplatin, and ABT-263 addition could be an effective strategy to improve the activity of chemo- or radio-therapy in SCLC. |
资助项目 | National Natural Science Foundation of China[81872438] ; National Natural Science Foundation of China[81672647] ; National Natural Science Foundation of China[81502632] ; National Natural Science Foundation of China[81372214] ; Natural Science Foundation of Anhui Province[1608085MH179] ; Key Technologies R and D Program of Anhui Province[1604a0802103] ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2016FXCX006] ; 100Talent Program of Chinese Academy of Sciences |
WOS关键词 | ABT-737 SYNERGIZES ; INDUCED APOPTOSIS ; PATHWAY ; FAMILY |
WOS研究方向 | Oncology |
语种 | 英语 |
出版者 | IOS PRESS |
WOS记录号 | WOS:000459543600006 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Key Technologies R and D Program of Anhui Province ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences ; 100Talent Program of Chinese Academy of Sciences |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/42108] |
专题 | 合肥物质科学研究院_中科院强磁场科学中心 医学物理与技术中心 |
通讯作者 | Hong, Bo; Lin, Wenchu |
作者单位 | 1.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei, Anhui, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Hong,Wang, Huogang,Deng, Ke,et al. The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer[J]. CANCER BIOMARKERS,2019,24(1):51-59. |
APA | Li, Hong,Wang, Huogang,Deng, Ke,Han, Wei,Hong, Bo,&Lin, Wenchu.(2019).The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer.CANCER BIOMARKERS,24(1),51-59. |
MLA | Li, Hong,et al."The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer".CANCER BIOMARKERS 24.1(2019):51-59. |
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