Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems | |
Sun, Xiao1,2; Zhang, Guilong1,2; Wu, Zhengyan1,2 | |
刊名 | CURRENT MEDICINAL CHEMISTRY |
2018 | |
卷号 | 25期号:25页码:3036-3057 |
关键词 | pH-responsive magnetic resonance contrast agents drug delivery systems contrast enhancement controlled release cancer diagnosis and chemotherapy |
ISSN号 | 0929-8673 |
DOI | 10.2174/0929867324666170406110642 |
英文摘要 | According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy. |
资助项目 | National Natural Science Foundation of China[21407151] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2015385] ; Key Program of Chinese Academy of Sciences[KSZD-EW-Z-022-05] ; Science and Technology Service Programs of Chinese Academy of Sciences[KFJ-STS-ZDTP-002] ; Science and Technology Service Programs of Chinese Academy of Sciences[KFJ-SW-STS-143] |
WOS关键词 | IRON-OXIDE NANOPARTICLES ; MESOPOROUS SILICA NANOPARTICLES ; RESPONSIVE CONTROLLED-RELEASE ; CANCER-THERAPY ; IN-VITRO ; PARAMAGNETIC LIPOSOMES ; POLYMERIC MICELLES ; GD-DTPA ; PHYSICOCHEMICAL PROPERTIES ; BIOIMAGING AGENT |
WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | BENTHAM SCIENCE PUBL LTD |
WOS记录号 | WOS:000447388100011 |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/39644] |
专题 | 合肥物质科学研究院_技术生物与农业工程研究所 |
通讯作者 | Wu, Zhengyan |
作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Xiao,Zhang, Guilong,Wu, Zhengyan. Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems[J]. CURRENT MEDICINAL CHEMISTRY,2018,25(25):3036-3057. |
APA | Sun, Xiao,Zhang, Guilong,&Wu, Zhengyan.(2018).Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems.CURRENT MEDICINAL CHEMISTRY,25(25),3036-3057. |
MLA | Sun, Xiao,et al."Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems".CURRENT MEDICINAL CHEMISTRY 25.25(2018):3036-3057. |
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