Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis

doi:10.1007/s11426-017-9198-y

CORC > 合肥物质科学研究院 > 中国科学院合肥物质科学研究院 > 中科院强磁场科学中心

	Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis
	Chen, Chen-Chen 1,2; Gao, Shuai 4; Ai, Hua-Song 4; Qu, Qian 3,4; Tian, Chang-Lin 1,2; Li, Yi-Ming 3
刊名	SCIENCE CHINA-CHEMISTRY
	2018-06-01
卷号	61 期号:6 页码:702-707
关键词	protein chemical synthesis calciseptine hydrazide based native chemical ligation racemic protein crystallography
ISSN号	1674-7291
DOI	10.1007/s11426-017-9198-y
英文摘要	Snake toxin Calciseptine as a natural antagonist of L-type calcium channel has potential drug values, but its structural information remains unknown. Here, we report the total chemical synthesis of Calciseptine by using hydrazide based native chemical ligation. The crystal structure of Calciseptine was determined by racemic protein crystallography technique. Compared to the structure of its homologous family protein, we found that Calciseptine is adopting a typical three-finger structure.
资助项目	National Natural Science Foundation of China[21572043] ; National Natural Science Foundation of China[21473176] ; Ministry of Science and Technology[2016YFA0400900] ; Ministry of Science and Technology[2015CB910103] ; Fundamental Research Funds for the Central Universities[PA2017GDQT0021]
WOS关键词	BLACK MAMBA VENOM ; PROTEIN CRYSTALLOGRAPHY ; PEPTIDE HYDRAZIDES ; BLOCKING ACTIVITY ; SHK TOXIN ; LIGATION ; RESIDUES ; BINDING ; SITE ; CHANNELOPATHIES
WOS研究方向	Chemistry
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000434719100013
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/36464]
专题	合肥物质科学研究院_中科院强磁场科学中心
通讯作者	Tian, Chang-Lin; Li, Yi-Ming
作者单位	1.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China 3.Hefei Univ Technol, Sch Biol & Med Engn, Hefei 230009, Anhui, Peoples R China 4.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
推荐引用方式 GB/T 7714	Chen, Chen-Chen,Gao, Shuai,Ai, Hua-Song,et al. Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis[J]. SCIENCE CHINA-CHEMISTRY,2018,61(6):702-707.
APA	Chen, Chen-Chen,Gao, Shuai,Ai, Hua-Song,Qu, Qian,Tian, Chang-Lin,&Li, Yi-Ming.(2018).Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis.SCIENCE CHINA-CHEMISTRY,61(6),702-707.
MLA	Chen, Chen-Chen,et al."Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis".SCIENCE CHINA-CHEMISTRY 61.6(2018):702-707.