Remarkable Response of Toripalimab Combined with Chemotherapy in Sarcomatoid Carcinoma of Palatine Tonsil: A Case Report

doi:10.2147/JMDH.S296584

	Remarkable Response of Toripalimab Combined with Chemotherapy in Sarcomatoid Carcinoma of Palatine Tonsil: A Case Report
	Huang, Jiahuan 1,2; Lei, Lei 1,2; Chen, Bo 2,3; Pan, Guoqiang 4; Wang, Xiaojiao 1,2; Fang, Meiyu 2,5
刊名	JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
	2021
卷号	14
关键词	chemotherapy combination therapy palatine tonsil cancer PD-1 inhibitor sarcomatoid carcinoma
ISSN号	1178-2390
DOI	10.2147/JMDH.S296584
通讯作者	Wang, Xiaojiao(wxiaojia0803@163.com) ; Fang, Meiyu(fangmy@zjcc.org.cn)
英文摘要	Background: Sarcomatoid carcinoma (SaCa) of the palatine tonsil is a rare and aggressive subset of head and neck (H&N) cancer which is characterized by insensitivity to surgery and radiotherapy and a poor prognosis. Immunotherapy has led advances in the treatment of melanoma and H&N cancer, but the combined effects of immunotherapy and chemotherapy have not been sufficiently investigated. Case Presentation: Herein, we report the case of 29-year-old Chinese women with local advanced non-resectable SaCa of the palatine tonsil who exhibited a substantial partial response to toripalimab and chemotherapy followed by radiation therapy. To the best of our knowledge, this is the first report of its successful application in this context. Conclusion: Toripalimab combined with chemotherapy may be an effective approach for locally advanced H&N cancer in rare categories of patients, which was the first application as far as we know.
WOS关键词	SQUAMOUS-CELL CARCINOMA ; LOCALLY ADVANCED HEAD ; NECK CANCERS ; RANDOMIZED-TRIAL ; OPEN-LABEL ; PEMBROLIZUMAB ; RECURRENT ; LARYNX ; CISPLATIN ; CETUXIMAB
WOS研究方向	Health Care Sciences & Services
语种	英语
出版者	DOVE MEDICAL PRESS LTD
WOS记录号	WOS:000629591600001
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121204]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Xiaojiao; Fang, Meiyu
作者单位	1.Univ Chinese Acad Sci, Dept Breast Med Oncol, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou 310022, Peoples R China 3.Univ Chinese Acad Sci, Dept Pathol, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Peoples R China 4.Wenzhou Med Univ, Dept Thorac Oncol, Wenzhou 325035, Peoples R China 5.Univ Chinese Acad Sci, Dept Med Oncol Rare Canc & Head & Neck Canc, Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Zhejiang Canc Hosp,Canc Hosp, Hangzhou 310022, Peoples R China
推荐引用方式 GB/T 7714	Huang, Jiahuan,Lei, Lei,Chen, Bo,et al. Remarkable Response of Toripalimab Combined with Chemotherapy in Sarcomatoid Carcinoma of Palatine Tonsil: A Case Report[J]. JOURNAL OF MULTIDISCIPLINARY HEALTHCARE,2021,14.
APA	Huang, Jiahuan,Lei, Lei,Chen, Bo,Pan, Guoqiang,Wang, Xiaojiao,&Fang, Meiyu.(2021).Remarkable Response of Toripalimab Combined with Chemotherapy in Sarcomatoid Carcinoma of Palatine Tonsil: A Case Report.JOURNAL OF MULTIDISCIPLINARY HEALTHCARE,14.
MLA	Huang, Jiahuan,et al."Remarkable Response of Toripalimab Combined with Chemotherapy in Sarcomatoid Carcinoma of Palatine Tonsil: A Case Report".JOURNAL OF MULTIDISCIPLINARY HEALTHCARE 14(2021).