A narrative review of risk factors and interventions for cancer-related cognitive impairment

doi:10.21037/atm-20-6443

	A narrative review of risk factors and interventions for cancer-related cognitive impairment
	Bai, Lu 1,2; Yu, Enyan 1,2
刊名	ANNALS OF TRANSLATIONAL MEDICINE
	2021
卷号	9
关键词	Cancer cognitive impairment risk factors treatment
ISSN号	2305-5839
DOI	10.21037/atm-20-6443
通讯作者	Yu, Enyan(yuenyan@aliyun.com)
英文摘要	Cancer-related cognitive impairment (CRCI) refers to a series of cognitive impairment symptoms associated with alternations in brain structure and function, caused by a non-central nervous system malignant tumor and its related treatment. CRCI may present as memory loss, impaired concentration, difficulty in multitasking and word retrieval, and reduced comprehension speed. CRCI has become one of the prevalent factors that compromise the quality of life for cancer survivors. Different treatments, including surgery, chemotherapy, radiotherapy, endocrine therapy, and targeted drugs, may contribute to CRCI. Meanwhile, patients' factors, including emotional challenges and genetic makeup, also contribute to the development of CRCI. The condition can be treated with using stimulants methylphenidate and modafinil, metabolites of nicotine: cotinine, antidepressants of fluoxetine and fluvoxamine, dementia drug of donepezil, and antioxidants ZnSO4, n-acetyl cysteine, propofol, and Chinese herbal of silver leaf medicine. Psychotherapies, including meditation and relaxation, cognitive rehabilitation training, along with physical therapies, including aerobic exercise, resistance training, balance training, yoga, qigong, tai chi electroencephalogram biofeedback, and acupuncture, are also beneficial in alleviating cancer-related cognitive impairment symptoms. In recent years, researchers have focused on factors related to the condition and on the available interventions. However, most research was conducted independently, and no review has yet summarized the latest findings. This review details and discusses the status of related factors and potential treatments for CRCI. We also supply specific recommendations to facilitate future research and integration in this field.
资助项目	National Natural Science Foundation of China[81771158]
WOS关键词	QUALITY-OF-LIFE ; ACUTE LYMPHOCYTIC-LEUKEMIA ; BREAST-CANCER ; ADJUVANT CHEMOTHERAPY ; LONGITUDINAL ASSESSMENT ; EXECUTIVE FUNCTION ; NEUROPSYCHOLOGICAL PERFORMANCE ; PHYSICAL-ACTIVITY ; APOLIPOPROTEIN-E ; HORMONE-THERAPY
WOS研究方向	Oncology ; Research & Experimental Medicine
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000614551200012
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/120616]
专题	中国科学院合肥物质科学研究院
通讯作者	Yu, Enyan
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Bai, Lu,Yu, Enyan. A narrative review of risk factors and interventions for cancer-related cognitive impairment[J]. ANNALS OF TRANSLATIONAL MEDICINE,2021,9.
APA	Bai, Lu,&Yu, Enyan.(2021).A narrative review of risk factors and interventions for cancer-related cognitive impairment.ANNALS OF TRANSLATIONAL MEDICINE,9.
MLA	Bai, Lu,et al."A narrative review of risk factors and interventions for cancer-related cognitive impairment".ANNALS OF TRANSLATIONAL MEDICINE 9(2021).