Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy

doi:10.1002/adhm.202001803

	Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy
	Zhao, Di 2,3; Jiang, Kai 2; Wang, Yuqi 2; Cheng, Jin 2; Mo, Fangli 2; Luo, Tao 2; Guo, Yuanyuan 1; Zhang, Chuan 1; Song, Jie 2,4
刊名	ADVANCED HEALTHCARE MATERIALS
	2021-01-12
关键词	controllable esterase response high loading efficiency lung targeting multi-drug resistance universal drug encapsulation
ISSN号	2192-2640
DOI	10.1002/adhm.202001803
通讯作者	Zhao, Di(zhaodi@sit.edu.cn) ; Song, Jie(sjie@sjtu.edu.cn)
英文摘要	Most anticancer drugs, particularly paclitaxel (PTX), are suffering the challenges of cancer chemotherapy due to their poor water-solubility, high toxicity under effective therapeutic dosages, and multi-drug resistance. Currently, nanoscale drug delivery systems (DDSs) represent an efficient platform to overcome the above challenges. However, those DDSs generally need a careful design of conjugation, complexation, or co-self-assembly. Herein, a facile out-of-the-box nanocapsule is developed not only to be easily packed with on-demand hydrophobic anticancer drugs (up to 76% of loading efficiency for PTX), but also to be loaded with other concomitant drugs for synergy therapy (Itraconazole (ITA) here as P-glycoprotein inhibitor for drug resistance and antiangiogenic agent for combination therapy with PTX). Three kinds of biocompatible poly(ethylene glycol) dimethacrylates (PEGDM) derivatives usually as cross-linking agents are selected and successfully constructed adequate nanocapsules with single monomer as shell materials. More importantly, as-prepared nanocapsules have abilities of esterase triggering and lung targeting. Both in vitro and in vivo studies showed that the drug-loaded nanocapsules can effectively inhibit tumor growth and vascular proliferation in PTX-resistant tumor models without apparent systemic toxicity. The above results demonstrate that the nanocapsule system provides an effective and universal strategy for lung targeting, esterase triggering, and synergy therapy.
资助项目	National Natural Science Foundation of China[81822024] ; National Natural Science Foundation of China[11761141006] ; Natural Science Foundation of Shanghai, China[19520714100] ; Natural Science Foundation of Shanghai, China[19ZR1475800] ; National Key Research and Development Program of China[2017YFC1200904] ; Medical Engineering Cross Project of Shanghai Jiaotong University[YG2017ZD07]
WOS关键词	IN-VITRO ; CANCER ; DELIVERY ; NANOPARTICLES ; GROWTH ; ANGIOGENESIS ; ITRACONAZOLE ; CHEMOTHERAPY ; DOCETAXEL ; MECHANISM
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000606896500001
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Shanghai, China ; National Key Research and Development Program of China ; Medical Engineering Cross Project of Shanghai Jiaotong University
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/120077]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhao, Di; Song, Jie
作者单位	1.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, State Key Lab Met Matrix Composites, 800 Dongchuan Rd, Shanghai 200240, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, Dept Instrument Sci & Engn, Inst Nano Biomed & Engn, Shanghai 200240, Peoples R China 3.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China 4.Univ Chinese Acad Sci, Canc Hosp, Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Di,Jiang, Kai,Wang, Yuqi,et al. Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2021.
APA	Zhao, Di.,Jiang, Kai.,Wang, Yuqi.,Cheng, Jin.,Mo, Fangli.,...&Song, Jie.(2021).Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy.ADVANCED HEALTHCARE MATERIALS.
MLA	Zhao, Di,et al."Out-of-the-Box Nanocapsules Packed with On-Demand Hydrophobic Anticancer Drugs for Lung Targeting, Esterase Triggering, and Synergy Therapy".ADVANCED HEALTHCARE MATERIALS (2021).