Second Primary Cancers After Kidney Cancers, and Kidney Cancers as Second Primary Cancers

doi:10.1016/j.euros.2020.12.007

	Second Primary Cancers After Kidney Cancers, and Kidney Cancers as Second Primary Cancers
	Zheng, Guoqiao 2,3,4,5; Sundquist, Kristina 1,5,6,7; Sundquist, Jan 1,5,6,7; Chen, Tianhui 8,9; Foersti, Asta 2,5,10,11; Hemminki, Otto 12,13; Hemminki, Kari 2,3,5,14,15
刊名	EUROPEAN UROLOGY OPEN SCIENCE
	2021-02-01
卷号	24
关键词	Cancer incidence Relative risk Second primary cancer Cancer etiology Sex difference
ISSN号	2666-1691
DOI	10.1016/j.euros.2020.12.007
通讯作者	Hemminki, Kari(K.Hemminki@dkfz.de)
英文摘要	Background: Second primary cancers (SPCs) are increasing due to improving survival in first primary cancers. Previous studies on SPCs in renal cell carcinoma (RCC) have focused on treatment and other risk factors, but data of RCC as an SPC are scarce. Objective: In this study, we want to elucidate the risk for any SPC after RCC, and in reverse order, for RCC as an SPC after any cancer. We additionally consider how family histories influence the risks. Design, setting, and participants: Patient data were obtained from the Swedish Cancer Registry from years 1990 through 2015, and family data were obtained from the Multigeneration Register. Outcome measurements and statistical analysis: We employed standardized incidence ratios to estimate bidirectional relative risks of subsequent cancer associated with RCC. Results and limitations: We identified 17 587 RCCs (60% in male patients). The highest increases for SPCs were observed for nervous system hemangioblastoma (HB; 26.8), adrenal (12.09) tumors, and renal pelvic cancer (6.32). In the reverse order, RCC as an SPC, nervous system HB (17.01), and adrenal tumors (15.34) were associated with the highest risks. Risks for many other sites (12 sites and subsites) were increased bidirectionally. For women, a total of seven sites and subsites were increased bidirectionally, and many were shared with men. The only significant sex difference in SPCs was the higher lung cancer risk in women (2.41) than in men (1.28). Patients with a family history of HBs or of prostate, colorectal and lung cancers showed high risks of these cancers as SPCs after RCC. Family history accounted for 30% of prostate cancers after RCC. Conclusions: The bidirectional study design was able to suggest risk factors for SPCs and offered a clinical take-home message urging to consider strategies for early detection and prevention of SPCs. Readily available information on lifestyle (eg, smoking) and family history (eg, prostate cancer) may reveal targets for risk reduction with prognostic benefits. Patient summary: Close to 10% of kidney cancer patients develop another cancer. The cause for these other cancers may not depend on kidney cancer. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology.
资助项目	China Scholarship Council[201606100057] ; Biomedicum Helsinki Foundation ; Finska lakaresallskapet grants ; European Union's Horizon 2020 research and innovation program[856620] ; Swedish Research Council
WOS关键词	RENAL-CELL CARCINOMA ; UPPER URINARY-TRACT ; UROTHELIAL CARCINOMA ; RISK ; STRATEGIES ; NEOPLASMS
WOS研究方向	Urology & Nephrology
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000609878400009
资助机构	China Scholarship Council ; Biomedicum Helsinki Foundation ; Finska lakaresallskapet grants ; European Union's Horizon 2020 research and innovation program ; Swedish Research Council
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/119802]
专题	中国科学院合肥物质科学研究院
通讯作者	Hemminki, Kari
作者单位	1.Shimane Univ, Sch Med, Dept Funct Pathol, Ctr Community Based Healthcare Res & Educ CoHRE, Matsue, Shimane, Japan 2.German Canc Res Ctr, Div Mol Genet Epidemiol, Heidelberg, Germany 3.German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 581, D-69120 Heidelberg, Germany 4.Heidelberg Univ, Fac Med, Heidelberg, Germany 5.Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden 6.Icahn Sch Med Mt Sinai, Dept Family Med & Community Hlth, New York, NY 10029 USA 7.Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA 8.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Canc Prevent, Hangzhou, Peoples R China 9.Chinese Acad Sci, Inst Canc & Basic Med, Hangzhou, Peoples R China 10.Hopp Childrens Canc Ctr KiTZ, Heidelberg, Germany
推荐引用方式 GB/T 7714	Zheng, Guoqiao,Sundquist, Kristina,Sundquist, Jan,et al. Second Primary Cancers After Kidney Cancers, and Kidney Cancers as Second Primary Cancers[J]. EUROPEAN UROLOGY OPEN SCIENCE,2021,24.
APA	Zheng, Guoqiao.,Sundquist, Kristina.,Sundquist, Jan.,Chen, Tianhui.,Foersti, Asta.,...&Hemminki, Kari.(2021).Second Primary Cancers After Kidney Cancers, and Kidney Cancers as Second Primary Cancers.EUROPEAN UROLOGY OPEN SCIENCE,24.
MLA	Zheng, Guoqiao,et al."Second Primary Cancers After Kidney Cancers, and Kidney Cancers as Second Primary Cancers".EUROPEAN UROLOGY OPEN SCIENCE 24(2021).