Nutritional Status and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study

doi:10.3389/fonc.2020.594687

	Nutritional Status and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study
	Shu, Zekai 1,4,5; Zeng, Ziyi 6,7; Yu, Bingqi 3; Huang, Shuang 4,5; Hua, Yonghong 4,5; Jin, Ting 4,5; Tao, Changjuan 4,5; Wang, Lei 4,5; Cao, Caineng 4,5; Xu, Zumin 8
刊名	FRONTIERS IN ONCOLOGY
	2020-11-06
卷号	10
关键词	radiation– induced oral mucositis radiotherapy nutritional status nasopharyngeal carcinoma (NPC) head and neck cancer
ISSN号	2234-943X
DOI	10.3389/fonc.2020.594687
通讯作者	Lu, Lixia(lulx@sysucc.org.cn) ; Chen, Yuanyuan(chenyy@zjcc.org.cn)
英文摘要	Background and Aims Malnutrition is a concern in patients with nasopharyngeal carcinoma (NPC) during chemoradiotherapy (CRT)/radiotherapy (RT), which is considered to be related with radiation-induced oral mucositis (ROM). The study aimed to evaluate the nutritional status of NPC patients during RT and investigate its association with ROM. Methods A prospective study was conducted in NPC patients. Patients were divided into three subgroups (mild, moderate, and severe groups) based on the duration of severe ROM (>= grade 3). Body weight, body mass index (BMI), albumin, prealbumin, NRS2002, and ROM grade were assessed on a weekly basis before and during CRT/RT. The statistical analysis was performed in the overall group and between three subgroups. Results A total of 176 patients were included. In the overall group, body weight and BMI kept decreasing since week 1 of RT, and NRS2002 score and ROM grade increased (p < 0.001). NRS2002 score and prealbumin levels were significantly different between each subgroup (p <= 0.046). Significant differences were observed in the proportion of patients receiving enteral nutrition, duration of parenteral nutrition, and total calories provided by nutritional support among three subgroups (p = 0.045-0.001). Conclusions Malnutrition occurred early in NPC patients and worsened continuously during RT. ROM was strongly associated with nutritional status. Nutritional support should be provided at the start of RT, especially in patients at high-risk of severe ROM.
资助项目	Qilu Pharmaceutical Co., Ltd.
WOS关键词	WEIGHT-LOSS ; NECK-CANCER ; RISK-FACTORS ; HEAD ; PREDICTORS ; MANAGEMENT ; OUTCOMES ; INDEX ; INTERRUPTIONS ; MALNUTRITION
WOS研究方向	Oncology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000590525800001
资助机构	Qilu Pharmaceutical Co., Ltd.
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/105314]
专题	中国科学院合肥物质科学研究院
通讯作者	Lu, Lixia; Chen, Yuanyuan
作者单位	1.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China 2.CSNO, Chinese Soc Nutr Oncol, Tianjin, Peoples R China 3.Zhejiang Hosp, Dept Oncol, Hangzhou, Peoples R China 4.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Radiat Oncol, Hangzhou, Peoples R China 6.Sun Yat Sen Univ, Canc Ctr, Dept Radiat Oncol, Guangzhou, Peoples R China 7.Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China,Canc Ctr, Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, Guangzhou, Peoples R China 8.Guangdong Med Univ, Affiliated Hosp, Canc Ctr, Zhanjiang, Peoples R China 9.Nanjing Med Univ, Dept Radiat Oncol, Affiliated Huaian Peoples Hosp 1, Huaian, Peoples R China 10.Hangzhou YITU Healthcare Technol Co Ltd, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Shu, Zekai,Zeng, Ziyi,Yu, Bingqi,et al. Nutritional Status and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study[J]. FRONTIERS IN ONCOLOGY,2020,10.
APA	Shu, Zekai.,Zeng, Ziyi.,Yu, Bingqi.,Huang, Shuang.,Hua, Yonghong.,...&Chen, Yuanyuan.(2020).Nutritional Status and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study.FRONTIERS IN ONCOLOGY,10.
MLA	Shu, Zekai,et al."Nutritional Status and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study".FRONTIERS IN ONCOLOGY 10(2020).