A materials-science perspective on tackling COVID-19

doi:10.1038/s41578-020-00247-y

	A materials-science perspective on tackling COVID-19
	Tang, Zhongmin 12,13; Kong, Na 12,13; Zhang, Xingcai 3; Liu, Yuan 12,13; Hu, Ping 4; Mou, Shan 5; Liljestrom, Peter 1; Shi, Jianlin 4; Tan, Weihong 5,6,7; Kim, Jong Seung 8
刊名	NATURE REVIEWS MATERIALS
	2020-10-14
ISSN号	2058-8437
DOI	10.1038/s41578-020-00247-y
通讯作者	Farokhzad, Omid C.(ofarokhzad@bwh.harvard.edu) ; Tao, Wei(wtao@bwh.harvard.edu)
英文摘要	Materials science provides tools and technologies for the protection against viral infections, as well as for the understanding, diagnosis, treatment and prevention of viral diseases. This Review discusses present and future directions in antiviral materials-science research, with a focus on COVID-19. The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in providing tools and technologies for antiviral research and treatment development. In this Review, we discuss previous efforts in materials science in developing imaging systems and microfluidic devices for the in-depth and real-time investigation of viral structures and transmission, as well as material platforms for the detection of viruses and the delivery of antiviral drugs and vaccines. We highlight the contribution of materials science to the manufacturing of personal protective equipment and to the design of simple, accurate and low-cost virus-detection devices. We then investigate future possibilities of materials science in antiviral research and treatment development, examining the role of materials in antiviral-drug design, including the importance of synthetic material platforms for organoids and organs-on-a-chip, in drug delivery and vaccination, and for the production of medical equipment. Materials-science-based technologies not only contribute to the ongoing SARS-CoV-2 research efforts but can also provide platforms and tools for the understanding, protection, detection and treatment of future viral diseases.
资助项目	US METAvivor Early Career Investigator Award[2018A020560] ; Harvard Medical School/Brigham and Women's Hospital Department of Anaesthesiology Basic Scientist Grant[2420 BPA075] ; Center for Nanomedicine Research Fund[2019A014810] ; Khoury Innovation Award[2020A003219] ; American Heart Association (AHA) Collaborative Science Award[2018A004190]
WOS关键词	MESSENGER-RNA VACCINES ; ZIKA VIRUS-INFECTION ; LABELED RABIES-VIRUS ; GENE-EXPRESSION ; CYTOKINE STORM ; INFLUENZA ; DELIVERY ; DNA ; NANOPARTICLES ; TRANSMISSION
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	NATURE RESEARCH
WOS记录号	WOS:000577270200002
资助机构	US METAvivor Early Career Investigator Award ; Harvard Medical School/Brigham and Women's Hospital Department of Anaesthesiology Basic Scientist Grant ; Center for Nanomedicine Research Fund ; Khoury Innovation Award ; American Heart Association (AHA) Collaborative Science Award
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/104500]
专题	中国科学院合肥物质科学研究院
通讯作者	Farokhzad, Omid C.; Tao, Wei
作者单位	1.Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden 2.Columbia Univ, Dept Biomed Engn, New York, NY USA 3.Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA 4.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogenes & Related Genes, Inst Mol Med IMM,Renji Hosp, Shanghai, Peoples R China 6.Hunan Univ, Aptamer Engn Ctr Hunan Prov, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Coll Biol,Mol Sci & Biomed, Changsha, Peoples R China 7.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Basic Med & Canc IBMC, Canc Hosp, Hangzhou, Peoples R China 8.Korea Univ, Dept Chem, Seoul, South Korea 9.MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA 10.MIT, Dept Chem Engn, Cambridge, MA 02139 USA
推荐引用方式 GB/T 7714	Tang, Zhongmin,Kong, Na,Zhang, Xingcai,et al. A materials-science perspective on tackling COVID-19[J]. NATURE REVIEWS MATERIALS,2020.
APA	Tang, Zhongmin.,Kong, Na.,Zhang, Xingcai.,Liu, Yuan.,Hu, Ping.,...&Tao, Wei.(2020).A materials-science perspective on tackling COVID-19.NATURE REVIEWS MATERIALS.
MLA	Tang, Zhongmin,et al."A materials-science perspective on tackling COVID-19".NATURE REVIEWS MATERIALS (2020).