Primary pulmonary lymphoepithelioma-like carcinoma

doi:10.1007/s12032-020-1344-3

	Primary pulmonary lymphoepithelioma-like carcinoma
	Fan, Ying 1,2,3,4; Li, Chenghui 2,3,4; Qin, Jing 2,3,4; Lu, Hongyang 2,3,4
刊名	MEDICAL ONCOLOGY
	2020-03-07
卷号	37
关键词	PPLELC Clinical features Molecular characteristics Treatment PD-L1 Prognosis
ISSN号	1357-0560
DOI	10.1007/s12032-020-1344-3
通讯作者	Lu, Hongyang(luhy@zjcc.org.cn)
英文摘要	Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is an extremely rare subtype of non-small-cell lung cancer (NSCLC) but differs from other NSCLC types. Most patients with PPLELC have almost no obvious clinical manifestations, and are often diagnosed in the advanced stage. Complete resection is the standard treatment for cases with early stage disease, while chemotherapy and radiotherapy are effective to some extent in late stage disease. High expression of PD-L1 in PPLELC tumor cells confers immunotherapy an important role in the treatment of PPLELC, and programmed death-1 (PD-1) inhibitors such as nivolumab and pembrolizumab may be optimal options for PPLELC patients. This review focuses on the clinical and pathologic features, treatment, and prognosis of PPLELC.
资助项目	Zhejiang Province Medical Science and Technology Project[2020ZH001]
WOS关键词	EPSTEIN-BARR-VIRUS ; COMPUTED-TOMOGRAPHY CHARACTERISTICS ; CELL LUNG-CARCINOMA ; MULTIMODALITY TREATMENT ; NIVOLUMAB ; ASSOCIATION ; FEATURES ; OUTCOMES ; PD-L1
WOS研究方向	Oncology
语种	英语
出版者	HUMANA PRESS INC
WOS记录号	WOS:000519062400001
资助机构	Zhejiang Province Medical Science and Technology Project
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/103797]
专题	中国科学院合肥物质科学研究院
通讯作者	Lu, Hongyang
作者单位	1.Wenzhou Med Univ, Clin Coll 1, Wenzhou 325035, Peoples R China 2.Chinese Acad Sci, ICBM, Hangzhou 310022, Peoples R China 3.Univ Chinese Acad Sci, Dept Thorac Med Oncol, Canc Hosp, Hangzhou 310022, Peoples R China 4.Zhejiang Canc Hosp, Zhejiang Key Lab Diag & Treatment Technol Thorac, Hangzhou 310022, Peoples R China
推荐引用方式 GB/T 7714	Fan, Ying,Li, Chenghui,Qin, Jing,et al. Primary pulmonary lymphoepithelioma-like carcinoma[J]. MEDICAL ONCOLOGY,2020,37.
APA	Fan, Ying,Li, Chenghui,Qin, Jing,&Lu, Hongyang.(2020).Primary pulmonary lymphoepithelioma-like carcinoma.MEDICAL ONCOLOGY,37.
MLA	Fan, Ying,et al."Primary pulmonary lymphoepithelioma-like carcinoma".MEDICAL ONCOLOGY 37(2020).