Thyroid V-50 is a risk factor for hypothyroidism in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a retrospective study

doi:10.1186/s13014-020-01490-x

	Thyroid V-50 is a risk factor for hypothyroidism in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a retrospective study
	Zhou, Ling 1,2,3,4; Chen, Jia 5; Shen, Wei 5; Chen, Zheng-Lu 4; Huang, Shuang 1,2,3; Tao, Chang-Juan 1,2,3; Chen, Ming 1,2,3; Yu, Zhong-Hua 6; Chen, Yuan-Yuan 1,2,3
刊名	RADIATION ONCOLOGY
	2020-03-23
卷号	15
关键词	Nasopharyngeal carcinoma Hypothyroidism Radiation therapy
DOI	10.1186/s13014-020-01490-x
通讯作者	Yu, Zhong-Hua(zhonghua_yu@126.com) ; Chen, Yuan-Yuan(chenyy@zjcc.org.cn)
英文摘要	Background We investigated the risk factors of radiation-induced thyroid dysfunction, then combined the clinical factors and optimum thyroid dosimetric parameters to predict the incidence rate of hypothyroidism (HT) and to guide individualized treatment. Methods A total of 206 patients with histologically proven nasopharyngeal carcinoma (NPC) treated at the Cancer Hospital of the University of Chinese Academy of Sciences between January 2015 and August 2018 were included. Dose-volume histogram (DVH) data, including mean dose, absolute volume, V-20, V-25, V-30, V-35, V-40, V-45, V-50,V- V-55, and V-60 were extracted and used as dosimetric parameters. A logistic regression analysis model was built to identify predictors related to HT occurring within 2 years. Results Sex, N stage, thyroid volume, mean thyroid dose, and thyroid V-20 and V-50 were significantly different between patients with and without HT. Logistic regression analysis showed that N stage, thyroid volume, and thyroid V-50 were independent predictors of HT. The radiosensitivity of the thyroid decreased as the thyroid volume increased. Patients with N stage > 1 had significantly higher HT incidence (37.38%) than patients with N stage <= 1 (13.11%). The incidence of HT was 54.55% in patients with thyroid V-50 > 24% and was 34.15% in patients with thyroid V-50 <= 24%. Conclusions The incidence of HT is significantly associated with N stage, thyroid volume, and thyroid V-50. More attention should be paid to patients with NPC with thyroid volume <= 12.82 cm(3) and advanced N stage disease.
资助项目	National Natural Science Foundation of China[81672971] ; Key Technologies Research and Development Program[2017YFC0113201]
WOS关键词	QUALITY-OF-LIFE ; NECK-CANCER-PATIENTS ; RADIOTHERAPY ; HEAD
WOS研究方向	Oncology ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	BMC
WOS记录号	WOS:000522186500001
资助机构	National Natural Science Foundation of China ; Key Technologies Research and Development Program
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/103601]
专题	中国科学院合肥物质科学研究院
通讯作者	Yu, Zhong-Hua; Chen, Yuan-Yuan
作者单位	1.Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou, Peoples R China 2.Chinese Acad Sci, ICBM, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, Hangzhou, Peoples R China 4.Guangdong Med Univ, Postgrad Educ, Zhanjiang, Peoples R China 5.Hangzhou YITU Healthcare Technol Co Ltd, Hangzhou, Peoples R China 6.Guangdong Med Univ, Dept Oncol, Affiliated Hosp, Zhanjiang, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Ling,Chen, Jia,Shen, Wei,et al. Thyroid V-50 is a risk factor for hypothyroidism in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a retrospective study[J]. RADIATION ONCOLOGY,2020,15.
APA	Zhou, Ling.,Chen, Jia.,Shen, Wei.,Chen, Zheng-Lu.,Huang, Shuang.,...&Chen, Yuan-Yuan.(2020).Thyroid V-50 is a risk factor for hypothyroidism in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a retrospective study.RADIATION ONCOLOGY,15.
MLA	Zhou, Ling,et al."Thyroid V-50 is a risk factor for hypothyroidism in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: a retrospective study".RADIATION ONCOLOGY 15(2020).