Nanogel Multienzyme Mimics Synthesized by Biocatalytic ATRP and Metal Coordination for Bioresponsive Fluorescence Imaging

doi:10.1002/anie.202002331

	Nanogel Multienzyme Mimics Synthesized by Biocatalytic ATRP and Metal Coordination for Bioresponsive Fluorescence Imaging
	Qi, Meiyuan 1; Pan, Hui 1; Shen, Hongdou 1; Xia, Xianmeng 1; Wu, Chu 1; Han, Xiaoke 1; He, Xingyue 1; Tong, Wei 2; Wang, Xia 1; Wang, Qigang 1
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2020-05-08
关键词	enzymes fluorescence imaging agents iron nanogels
ISSN号	1433-7851
DOI	10.1002/anie.202002331
通讯作者	Wang, Xia(15174@tongji.edu.cn) ; Wang, Qigang(wangqg66@tongji.edu.cn)
英文摘要	The design of enzyme mimics from stable and nonprotein systems is especially attractive for applications in highly specific cancer diagnosis and treatment, and it has become an emerging field in recent years. Herein, metal crosslinked polymeric nanogels (MPGs) were prepared using Fe-II ion coordinated biocompatible acryloyl-lysine polymer brushes obtained from an enzyme-catalyzed atomic transfer radical polymerization (ATRPase) method. The monoatomic and highly dispersed Fe ions in the MPGs serve as efficient crosslinkers of the gel network, and also as active centers of multienzyme mimics of superoxide dismutase (SOD) and peroxidase (POD). The catalytic activities were compared to those of conventional Fe-based nanozymes. Studies on both cells and animals verify that efficient reactive oxygen species (ROS) responsive biofluorescence imaging can be successfully realized using the MPGs.
资助项目	National Natural Science Foundation of China[51773155] ; National Natural Science Foundation of China[51873156] ; National Key Research and Development Program[2016YFA0100800] ; National Key Research and Development Program[2018YFC1803100]
WOS关键词	ORGANIC-FRAMEWORK NANOSHEETS ; HYBRID NANOGELS ; BINDING ; NANOPARTICLES ; DESIGN ; GROWTH ; ENZYME ; ACIDS ; OXIDE ; IRON
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000530871300001
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/103293]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Xia; Wang, Qigang
作者单位	1.Tongji Univ, Sch Chem Sci & Engn, 1239 Siping Rd, Shanghai 200092, Peoples R China 2.Chinese Acad Sci, High Field Magnet Lab, 350 Shushanhu Rd, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Qi, Meiyuan,Pan, Hui,Shen, Hongdou,et al. Nanogel Multienzyme Mimics Synthesized by Biocatalytic ATRP and Metal Coordination for Bioresponsive Fluorescence Imaging[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020.
APA	Qi, Meiyuan.,Pan, Hui.,Shen, Hongdou.,Xia, Xianmeng.,Wu, Chu.,...&Wang, Qigang.(2020).Nanogel Multienzyme Mimics Synthesized by Biocatalytic ATRP and Metal Coordination for Bioresponsive Fluorescence Imaging.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA	Qi, Meiyuan,et al."Nanogel Multienzyme Mimics Synthesized by Biocatalytic ATRP and Metal Coordination for Bioresponsive Fluorescence Imaging".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020).