Clinicopathologic characteristics and outcomes of papillary thyroid carcinoma in younger patients

doi:10.1097/MD.0000000000019795

	Clinicopathologic characteristics and outcomes of papillary thyroid carcinoma in younger patients
	Lu, Yi 2,7; Jiang, Lin 3,8; Chen, Chao 3,8; Chen, Haitao 4; Yao, Qinghua 1,5,6,9
刊名	MEDICINE
	2020-04-01
卷号	99
关键词	clinicopathologic features disease-free survival papillary thyroid carcinoma recurrence
ISSN号	0025-7974
DOI	10.1097/MD.0000000000019795
通讯作者	Yao, Qinghua(yaoqh@zjcc.org.cn)
英文摘要	In the 7th edition of AJCC staging system, cervical lymph node metastases (LNM) in papillary thyroid carcinoma (PTC) is considered as a poorer prognostic indicator only in patients aged 45 years or older, but as a low-risk factor in patients younger than 45 years. The objective of this study is to investigate the influence of cervical LNM on prognostic outcomes of young patients (<45 years' old) with PTC. We carried out a retrospective analysis of 1896 PTC patients younger than 45 years' old at diagnosis, who were firstly treated in our department between January 2005 and December 2014. Clinicopathologic features, recurrences, disease-free survival (DFS) were recorded and analyzed. A total of 1896 consecutive patients were identified, comprising of 426 males and 1470 females after a median follow-up period of 40 months (3-129 months) from initial surgery to disease recurrence or to the end of follow-up. The rate of recurrence was 2.16% (n=41). The DFS rates for a 1-year, 3-year, or 5-year team were 99.1%, 97.8%, or 97.4%, respectively. Univariate analysis showed that diagnosed age similar to 30 years, tumor size >1.0cm, extrathyroidal extension, multifocal lesions, lesions in bilateral lobes, central neck LNM, and lateral neck LNM were associated with a worse DFS. Multivariate analysis showed that only central neck LNM and lateral neck LNM were significant independent prognostic factors for DFS (P<.001). For patients with papillary thyroid microcarcinoma, cervical LNM were also identified as independent risk factors for DFS (P<.001). LNM have prognostic significance for DFS in PTC patients younger than 45 years. It indicated that PTC patients (<45 years old) with LNM, especially lateral neck LNM, were understaged by the 7th edition of AJCC staging system. Thus, radical resection of primary tumor and metastatic lymph nodes, frequent follow-up, and strict TSH suppression should be taken for young patients with PTC.
WOS关键词	LYMPH-NODE METASTASIS ; LOCOREGIONAL RECURRENCE ; PREDICTIVE FACTORS ; NECK DISSECTION ; CANCER ; SURVIVAL ; PATTERN
WOS研究方向	General & Internal Medicine
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:000531848600053
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/103289]
专题	中国科学院合肥物质科学研究院
通讯作者	Yao, Qinghua
作者单位	1.Key Lab Tradit Chinese & Western Med Oncol Zhejia, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Dept Nutr, Inst Canc Res & Basic Med Sci, Chinese Acad Sci,Canc Hosp, Hangzhou 310022, Peoples R China 3.Univ Chinese Acad Sci, Dept Head & Neck Surg, Inst Canc Res & Basic Med Sci, Chinese Acad Sci,Canc Hosp, Hangzhou 310022, Peoples R China 4.Zhejiang Chinese Med Univ, First Clin Coll, Hangzhou 310053, Zhejiang, Peoples R China 5.Univ Chinese Acad Sci, Dept Integrated Chinese & Western Med, Inst Canc Res & Basic Med Sci, Chinese Acad Sci,Canc Hosp, Hangzhou 310022, Peoples R China 6.Univ Chinese Acad Sci, Key Lab Tradit Chinese Med Oncol, Inst Canc Res & Basic Med Sci, Chinese Acad Sci,Canc Hosp, Hangzhou 310022, Peoples R China 7.Univ Chinese Acad Sci, Dept Nutr, Inst Canc Res & Basic Med Sci, Chinese Acad Sci,Canc Hosp,Zhejiang Canc Hosp, Hangzhou, Peoples R China 8.Univ Chinese Acad Sci, Dept Head & Neck Surg, Inst Canc Res & Basic Med Sci, Chinese Acad Sci,Canc Hosp,Zhejiang Canc Hosp, Hangzhou, Peoples R China 9.Univ Chinese Acad Sci, Dept Integrated Chinese & Western Med, Inst Canc Res & Basic Med Sci, Chinese Acad Sci,Canc Hosp,Zhejiang Canc Hosp, 1 Banshan East Rd, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Lu, Yi,Jiang, Lin,Chen, Chao,et al. Clinicopathologic characteristics and outcomes of papillary thyroid carcinoma in younger patients[J]. MEDICINE,2020,99.
APA	Lu, Yi,Jiang, Lin,Chen, Chao,Chen, Haitao,&Yao, Qinghua.(2020).Clinicopathologic characteristics and outcomes of papillary thyroid carcinoma in younger patients.MEDICINE,99.
MLA	Lu, Yi,et al."Clinicopathologic characteristics and outcomes of papillary thyroid carcinoma in younger patients".MEDICINE 99(2020).