Non-thermal plasma with metformin synergistically induces cell death via upregulating AMPK to suppress energy metabolism

doi:10.1088/1361-6463/ab938a

	Non-thermal plasma with metformin synergistically induces cell death via upregulating AMPK to suppress energy metabolism
	Cui, Shujun 2,3; Chen, Guodong 2; Yu, K. N.4,5; Cheng, Cheng 6; Han, Wei 1,2,7
刊名	JOURNAL OF PHYSICS D-APPLIED PHYSICS
	2020-09-16
卷号	53
关键词	non-thermal plasma metformin AMP-activated protein kinase energy metabolism
ISSN号	0022-3727
DOI	10.1088/1361-6463/ab938a
通讯作者	Han, Wei(hanw@hfcas.ac.cn)
英文摘要	Non-thermal plasma (NTP) has a selective killing effect on a variety of cancer cellsin vivoandin vitro, and is considered a potential tumor therapy. In this study, we found that metformin, which has shown promising antitumor effects in previous studies, with NTP synergistically increased cell death including apoptosis in colon cancer cell lines via reducing mitochondrial oxidative phosphorylation and intracellular adenosine triphosphate exhausting cellular energy, mediated through activation of AMP-activated protein kinase (AMPK). Reactive oxygen species was revealed to modulate the activation of AMPK after NTP exposure. Considering the safety and wide clinical use of metformin, the combination of metformin and NTP showed great potential in cancer therapy.
资助项目	National Key R&D Program of China[2019YFC0119000] ; Chinese National Natural Science Foundation[81573093] ; Chinese National Natural Science Foundation[U1632145] ; CASHIPS Director's Fund[YZJJ 2018QN19] ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; State Key Laboratory in Marine Pollution, City University of Hong Kong[IRF/0024]
WOS关键词	ACTIVATED PROTEIN-KINASE ; CANCER PREVENTION ; COMPLEX 1 ; APOPTOSIS ; ROS ; INDUCTION
WOS研究方向	Physics
语种	英语
出版者	IOP PUBLISHING LTD
WOS记录号	WOS:000549872400001
资助机构	National Key R&D Program of China ; Chinese National Natural Science Foundation ; CASHIPS Director's Fund ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection ; State Key Laboratory in Marine Pollution, City University of Hong Kong
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/102961]
专题	中国科学院合肥物质科学研究院
通讯作者	Han, Wei
作者单位	1.Soochow Univ, Jiangsu Higher Educ Inst, Collaborat Innovat Ctr Radiat Med, Suzhou, Jiangsu, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei, Anhui, Peoples R China 3.Univ Sci & Technol China, Hefei, Anhui, Peoples R China 4.City Univ Hong Kong, Dept Phys, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China 5.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China 6.Chinese Acad Sci, Inst Plasma Sci & Technol, Hefei Inst Phys Sci, Hefei, Anhui, Peoples R China 7.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Cui, Shujun,Chen, Guodong,Yu, K. N.,et al. Non-thermal plasma with metformin synergistically induces cell death via upregulating AMPK to suppress energy metabolism[J]. JOURNAL OF PHYSICS D-APPLIED PHYSICS,2020,53.
APA	Cui, Shujun,Chen, Guodong,Yu, K. N.,Cheng, Cheng,&Han, Wei.(2020).Non-thermal plasma with metformin synergistically induces cell death via upregulating AMPK to suppress energy metabolism.JOURNAL OF PHYSICS D-APPLIED PHYSICS,53.
MLA	Cui, Shujun,et al."Non-thermal plasma with metformin synergistically induces cell death via upregulating AMPK to suppress energy metabolism".JOURNAL OF PHYSICS D-APPLIED PHYSICS 53(2020).