Therapeutic patterns and outcomes in older patients (aged >= 65 years) with stage II-IVB Nasopharyngeal Carcinoma: an investigational study from SEER database

doi:10.7150/jca.46201

	Therapeutic patterns and outcomes in older patients (aged >= 65 years) with stage II-IVB Nasopharyngeal Carcinoma: an investigational study from SEER database
	Piao, Yongfeng 6,7,8,9; Jiang, Chuner 4,5,9; Yan, Fengqin 6,7,8,9; Ye, Zhimin 6,7,8,9; Fu, Zhenfu 6,7,8,9; Jiang, Haitao 2,3,9; Jiang, Yangming 1; Wang, Yuezhen 6,7,8,9; Wang, Fangzheng 6,7,8,9
刊名	JOURNAL OF CANCER
	2020
卷号	11
关键词	nasopharyngeal carcinoma older therapeutic pattern survival prognosis
ISSN号	1837-9664
DOI	10.7150/jca.46201
通讯作者	Wang, Yuezhen(wangyz@zjcc.org.cn) ; Wang, Fangzheng(wangfz76@126.com)
英文摘要	Purpose: Currently, the optimal treatment regimens for older nasopharyngeal carcinoma (NPC) patients remained unclear. The aim of this retrospective study is to investigate therapeutic patterns and survival outcomes for a cohort of older NPC patients receiving radiation therapy (RT) with or without chemotherapy (CT). Methods: The clinical data of 529 patients with aged >= 65 years and NPC, who were identified within the Surveillance, Epidemiology, and End Results (SEER) registry (years 2004-2015), were collected and retrospectively reviewed. Among these patients, 74 patients treated with RT alone and 455 cases were administrated for RT plus CT. Kaplan-Meier analysis was used to evaluate overall survival (OS) and cancer-specific survival (CSS). The differences in OS and CSS were compared using Log-rank test. Results: The estimated OS and CSS rates at 5 years were 48.9% and 59.6%, respectively. Univariate analysis indicated that age, histology, T stage, and clinical stage were independent prognosticators of OS and CSS, while treatment option was only associated with OS. Multivariate analysis demonstrated that age, T stage, histology, and therapeutic strategy were correlated with OS, while age, T stage and histology were independent prognostic factors of CSS. Subgroup analyses showed that the combination of RT and CT yielded better OS and CSS in patients with stage T3 or N2 or III. Conclusion: Among these NPC patients with aged >= 65 years reported in the SEER database, treatment with RT plus CT provided longer OS than those treated with radiation therapy alone. Moreover, the combination of RT and CT obtained favorable OS and CSS in NPC patient stage T3 or N2 or III.
资助项目	Medical and Health Science and Technology Program of Zhejiang Province[2020KY084] ; Medical and Health Science and Technology Program of Zhejiang Province[2019KY041] ; Medical and Health Science and Technology Program of Zhejiang Province[2013KYB033] ; Medical and Health Science and Technology Program of Zhejiang Province[2009B026] ; Medical and Health Science and Technology Program of Zhejiang Province[2006A016] ; Medical and Health Science and Technology Program of Zhejiang Province[2005B012] ; Medical and Health Science and Technology Program of Zhejiang Province[2004B014] ; National Natural Science Foundation of China[81502647]
WOS关键词	ELDERLY-PATIENTS ; PHASE-III ; CONCURRENT CHEMORADIOTHERAPY ; RADIOTHERAPY ; CANCER ; SURVIVAL ; CHEMOTHERAPY
WOS研究方向	Oncology
语种	英语
出版者	IVYSPRING INT PUBL
WOS记录号	WOS:000554984800003
资助机构	Medical and Health Science and Technology Program of Zhejiang Province ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/70965]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Yuezhen; Wang, Fangzheng
作者单位	1.Chinese Acad Sci, Dept Didital Earth, Inst Remote Sensing & Didital Earth, Beijing 100101, Peoples R China 2.Zhejiang Canc Hosp, Dept Radiol, Hangzhou 310022, Zhejiang, Peoples R China 3.Univ Chinese Acad Sci, Dept Radiol, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 4.Zhejiang Canc Hosp, Dept Breast Tumor Surg, Hangzhou 310022, Zhejiang, Peoples R China 5.Univ Chinese Acad Sci, Dept Breast Tumor Surg, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 6.Key Lab Radiat Oncol Zhejiang Prov, Hangzhou 310022, Zhejiang, Peoples R China 7.Zhejiang Canc Hosp, Dept Radiat Oncol, Zhejiang Hangzhou, Hangzhou 310022, Zhejiang, Peoples R China 8.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Zhejiang, Peoples R China 9.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Piao, Yongfeng,Jiang, Chuner,Yan, Fengqin,et al. Therapeutic patterns and outcomes in older patients (aged >= 65 years) with stage II-IVB Nasopharyngeal Carcinoma: an investigational study from SEER database[J]. JOURNAL OF CANCER,2020,11.
APA	Piao, Yongfeng.,Jiang, Chuner.,Yan, Fengqin.,Ye, Zhimin.,Fu, Zhenfu.,...&Wang, Fangzheng.(2020).Therapeutic patterns and outcomes in older patients (aged >= 65 years) with stage II-IVB Nasopharyngeal Carcinoma: an investigational study from SEER database.JOURNAL OF CANCER,11.
MLA	Piao, Yongfeng,et al."Therapeutic patterns and outcomes in older patients (aged >= 65 years) with stage II-IVB Nasopharyngeal Carcinoma: an investigational study from SEER database".JOURNAL OF CANCER 11(2020).