Mycoplasma hyopneumoniaeevades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu) | |
Yu, Yanfei8,9; Wang, Jia7,9; Han, Rui6,9; Wang, Li9; Zhang, Lei9; Zhang, Amy Yimin5; Xin, Jiuqing4; Li, Shaoli3; Zeng, Yanhua2; Shao, Guoqing8,9 | |
刊名 | VIRULENCE |
2020 | |
卷号 | 11 |
关键词 | Mycoplasma elongation factor Tu complement factor H complement activation bacterial adhesion |
ISSN号 | 2150-5594 |
DOI | 10.1080/21505594.2020.1806664 |
通讯作者 | Feng, Zhixin(fzxjaas@163.com) ; Xiong, Qiyan(qiyanxiongnj@163.com) |
英文摘要 | Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we revealed that many mycoplasmas, such asMycoplasma hyopneumoniae, Mycoplasma hyorhinis, Mycoplasma hyosynoviae, Mycoplasma gallisepticum, Mycoplasma pneumoniae, Mycoplasma genitalium, Mycoplasma flocculare, andMycoplasma boviscould hijack factor H such that they present themselves as a host tissue and thus escape from complement attack. Furthermore, the mechanism of recruiting factor H was identified inM. hyopneumoniae. M. hyopneumoniaebinds factor H via factor H binding proteins, such as elongation factor thermo unstable (EF-Tu), P146, pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha (PdhA), P46, Pyruvate dehydrogenase E1 component subunit beta (PdhB), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and three different hypothetical proteins. The binding of factor H by EF-Tu further contributes to decreased C3 deposition on theM. hyopneumoniaesurface and ultimately blocks further complement activation. In fact, binding of factor H occurs in a multifactorial manner; factor H is not only exploited byM. hyopneumoniaevia its regulator activity to help mycoplasmas escape from complement killing, but also increasesM. hyopneumoniaeadhesion to swine tracheal epithelial cells, partially through EF-Tu. Meanwhile, the high sequence identity among EF-Tu proteins in the above-mentioned mycoplasmas implied the universality of the mechanism. This is the first report that mycoplasmas can escape complement killing by binding to factor H. |
资助项目 | National Natural Science Foundation of China[31700158] ; National Natural Science Foundation of China[31770193] |
WOS关键词 | NONTYPABLE HAEMOPHILUS-INFLUENZAE ; MEMBRANE PROTEIN P5 ; SURFACE PROTEIN ; STREPTOCOCCUS-SUIS ; SERUM RESISTANCE ; CONTRIBUTES ; PIGS ; AMPLIFICATION ; FIBRONECTIN ; PERSISTENCE |
WOS研究方向 | Immunology ; Infectious Diseases ; Microbiology |
语种 | 英语 |
出版者 | TAYLOR & FRANCIS INC |
WOS记录号 | WOS:000561128300001 |
资助机构 | National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/70623] |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Feng, Zhixin; Xiong, Qiyan |
作者单位 | 1.Jiangsu Univ, Inst Life Sci, Zhenjiang, Jiangsu, Peoples R China 2.Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hengyang, Peoples R China 3.Capital Inst Pediat, Dept Bacteriol, Beijing, Peoples R China 4.Chinese Acad Agr Sci, Harbin Vet Res Inst, Harbin, Peoples R China 5.Cornell Univ, Coll Vet Med, Cornell, NY USA 6.Chinese Acad Sci, High Magnet Field Lab, Hefei, Peoples R China 7.Univ KwaZulu Natal, Coll Agr Engn & Sci, Durban, South Africa 8.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Jiangsu, Peoples R China 9.Jiangsu Acad Agr Sci, Natl Ctr Engn Res Vet Bioprod, Inst Vet Med, Key Lab Vet Biol Engn & Technol,Minist Agr, Nanjing, Peoples R China |
推荐引用方式 GB/T 7714 | Yu, Yanfei,Wang, Jia,Han, Rui,et al. Mycoplasma hyopneumoniaeevades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu)[J]. VIRULENCE,2020,11. |
APA | Yu, Yanfei.,Wang, Jia.,Han, Rui.,Wang, Li.,Zhang, Lei.,...&Xiong, Qiyan.(2020).Mycoplasma hyopneumoniaeevades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu).VIRULENCE,11. |
MLA | Yu, Yanfei,et al."Mycoplasma hyopneumoniaeevades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu)".VIRULENCE 11(2020). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论