| Supervillin promotes tumor angiogenesis in liver cancer | |
| Zhao, Chenggang3,4; Zhao, Zhiyang3,4; Wang, Zhen2,4; Hu, Lizhu3,4; Wang, Hongzhi1,4; Fang, Zhiyou1,4 | |
| 刊名 | ONCOLOGY REPORTS
 |
| 2020-08-01 | |
| 卷号 | 44 |
| 关键词 | supervillin vascular endothelial growth factor p38 vascular mimicry liver cancer |
| ISSN号 | 1021-335X |
| DOI | 10.3892/or.2020.7621 |
| 通讯作者 | Fang, Zhiyou(z.fang@cmpt.ac.cn) |
| 英文摘要 | Tumor angiogenesis is a hallmark of liver cancer and is necessary for tumor growth and progression. Supervillin (SVIL) is highly expressed and implicated in several malignant processes of liver cancer. However, the functional relationships between SVIL and tumor angiogenesis in liver cancer have not yet been fully elucidated. The present study was based on bioinformatics analysis, patient tissue sample detection, three-dimensional simulated blood vessel formation, a series of cytological experiments and mouse models. The results demonstrated the important role of SVIL in the progression of malignant liver cancer and tumor angiogenesis, both in terms of vasculogenic mimicry (VM) and endothelium-dependent vessel (EDV) development. SVIL knockdown inhibited VM formation and induced tumor cell apoptosis via the VEGF-p38 signaling axis and through various VM-associated transcriptional factors, including vascular endothelial-cadherin, matrix metalloproteinase 9/12 and migration-inducing protein 7. SVIL may therefore be considered a potential tumor vascular biomarker and a promising therapeutic target for patients with liver cancer. |
| 资助项目 | National Natural Science Foundation of China[31571433] ; National Natural Science Foundation of China[81773131] ; National Natural Science Foundation of China[81872066] ; Anhui Provincial Natural Science Foundation[1608085MH180] ; Anhui Provincial Natural Science Foundation[1808085QH272] ; Innovative program of the Development Foundation of Hefei Center for Physical Science and Technology[2017FXCX008] ; CASHIPS Director's Fund[YZJJ201704] |
| WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; P38 MAP KINASE ; VASCULOGENIC MIMICRY ; HEPATOCELLULAR-CARCINOMA ; F-ACTIN ; ACTIVATION ; CADHERIN ; PROTEIN ; CELLS ; PROLIFERATION |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | SPANDIDOS PUBL LTD |
| WOS记录号 | WOS:000567188700024 |
| 资助机构 | National Natural Science Foundation of China ; Anhui Provincial Natural Science Foundation ; Innovative program of the Development Foundation of Hefei Center for Physical Science and Technology ; CASHIPS Director's Fund |
| 内容类型 | 期刊论文 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/70373]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Fang, Zhiyou |
| 作者单位 | 1.Chinese Acad Sci, Hefei Canc Hosp, Dept Pathol & Lab Med, Hefei 230031, Anhui, Peoples R China 2.Chinese Acad Sci, Hefei Inst Stem Cell & Regenerat Med, Guangzhou Inst Biomed & Hlth, Hefei 230088, Anhui, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 4.Chinese Acad Sci, Ctr Med Phys & Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, 350 Shushan Hu Rd, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Chenggang,Zhao, Zhiyang,Wang, Zhen,et al. Supervillin promotes tumor angiogenesis in liver cancer[J]. ONCOLOGY REPORTS,2020,44. |
| APA | Zhao, Chenggang,Zhao, Zhiyang,Wang, Zhen,Hu, Lizhu,Wang, Hongzhi,&Fang, Zhiyou.(2020).Supervillin promotes tumor angiogenesis in liver cancer.ONCOLOGY REPORTS,44. |
| MLA | Zhao, Chenggang,et al."Supervillin promotes tumor angiogenesis in liver cancer".ONCOLOGY REPORTS 44(2020). |
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