Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology

	Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology
刊名	SCIENCE CHINA-LIFE SCIENCES
	2017
卷号	60
关键词	SQUAMOUS-CELL CARCINOMA HEPATOCELLULAR-CARCINOMA UP-REGULATION PROMOTES INVASION PROLIFERATION INVASIVENESS MIGRATION FAMILY LUNG Kindlin-1 Kindlin-2 esophageal cancer epidemiology
ISSN号	1674-7305
其他题名	Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology
英文摘要	Esophageal cancer (EC) is one of the most lethal malignancies in China, but the etiology and risk factors remain unclear. The integrin-interacting proteins Kindlin-1 and Kindlin-2 are focal adhesion molecules that activate transmembrane receptor integrins and regulate tumor cell growth, invasion, and metastasis. Here, we report that Kindlin-1 and Kindlin-2 are differentially expressed among Chinese EC patients. For this, Kindlin-1 and Kindlin-2 expression was evaluated in 220 EC patients by immunohistochemistry (IHC) and found to be correlated with the EC progression, along with a variety of epidemiologic parameters, including smoking, family EC history, and EC invasion status. Moreover, data downloaded from the Oncomine database revealed that both Kindlin-1 and Kindlin-2 were upregulated in ECs compared with normal esophageal tissues; although Kindlin-1 was highly expressed in well-differentiated tumors, whereas Kindlin-2 was more prevalent in poorly differentiated tumors. Collectively, these data suggest that Kindlin-1 may inhibit, while Kindlin-2 may promote, EC progression. This study, for the first time, linked the expression of Kindlin-1 and Kindlin-2 with EC family genetic background and living habits, which may help further our understanding of the various causes of EC.
资助项目	[Ministry of Science and Technology of China] ; [National Natural Science Foundation of China] ; [Beijing Natural Science Foundation] ; [111 Project of the Ministry of Education] ; [Peking University] ; [Leading Academic Discipline Project of Beijing Education Bureau]
语种	英语
CSCD记录号	CSCD:6150316
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/69976]
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology[J]. SCIENCE CHINA-LIFE SCIENCES,2017,60.
APA	(2017).Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology.SCIENCE CHINA-LIFE SCIENCES,60.
MLA	"Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology".SCIENCE CHINA-LIFE SCIENCES 60(2017).