Emerging transporter-targeted nanoparticulate drug delivery systems

	Emerging transporter-targeted nanoparticulate drug delivery systems
刊名	ACTA PHARMACEUTICA SINICA B
	2019
卷号	9
关键词	BLOOD-BRAIN-BARRIER POLY(ETHYLENE GLYCOL)-CO-POLY(TRIMETHYLENE CARBONATE) MESOPOROUS SILICA NANOPARTICLES ORAL DELIVERY SIRNA DELIVERY TUMOR HETEROGENEITY CHOLINE TRANSPORTER DOCETAXEL DELIVERY LOADED LIPOSOMES OLEATE PRODRUG Transporter Nano-DDS Oral delivery Brain-targeting Tumor-targeting
ISSN号	2211-3835
英文摘要	Transporter-targeted nanoparticulate drug delivery systems (nano-DDS) have emerged as promising nanoplatforms for efficient drug delivery. Recently, great progress in transporter-targeted strategies has been made, especially with the rapid developments in nanotherapeutics. In this review, we outline the recent advances in transporter-targeted nano-DDS. First, the emerging transporter-targeted nano-DDS developed to facilitate oral drug delivery are reviewed. These include improvements in the oral absorption of protein and peptide drugs, facilitating the intravenous-to-oral switch in cancer chemotherapy. Secondly, the recent advances in transporter-assisted brain-targeting nano-DDS are discussed, focusing on the specific transporter-based targeting strategies. Recent developments in transporter mediated tumor-targeting drug delivery are also discussed. Finally, the possible transport mechanisms involved in transporter-mediated endocytosis are highlighted, with special attention to the latest findings of the interactions between membrane transporters and nano-DDS. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license ((http://creativecommons.org/licenses/by-nc-nd/4.0)
资助项目	[National Natural Science Foundation of China] ; [China Postdoctoral Science Foundation]
语种	英语
CSCD记录号	CSCD:6423115
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/67830]
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. Emerging transporter-targeted nanoparticulate drug delivery systems[J]. ACTA PHARMACEUTICA SINICA B,2019,9.
APA	(2019).Emerging transporter-targeted nanoparticulate drug delivery systems.ACTA PHARMACEUTICA SINICA B,9.
MLA	"Emerging transporter-targeted nanoparticulate drug delivery systems".ACTA PHARMACEUTICA SINICA B 9(2019).