Copy number variations of TOP2B gene are associated with growth traits in Chinese sheep breeds

	Copy number variations of TOP2B gene are associated with growth traits in Chinese sheep breeds
	Toremurat, Zhansaya; Ibrahim, Elsaeid Elnour; Huang, Yong-Zhen; Lan, Xianyong; Pi, Li; Chaogetu, Buren; Hu, Linyong; Chen, Hong
刊名	ANIMAL BIOTECHNOLOGY
	2020
关键词	CNVs sheep TOP2B gene growth traits association
英文摘要	Copy number variations are primary source of genetic variations, which are associated with essential traits in many organisms. During recent years, there have been numerous research works that reveal functions of CNV. However, these studies provide only several references about copy number variations in the sheep genome. In this study, we examined the copy number variation of theTOP2Bgene in three Chinese sheep breeds (Chaka sheep, Hu sheep, Small-tailed Han sheep) and performed correlation analysis with growth traits, to detect the influence of CNVs. TOP2B copy numbers were divided into three distribution groups (gain, median, loss) in three Chinese sheep breeds. The distribution amount of copy number < 2 ofTOP2BCNVs was dominant in all sheep breeds. The statistical analysis showed thatTOP2BCNV had a significant effect on body length in CK sheep (p < 0.05), and effects on chest circumference, canon circumference (p < 0.05) in HU sheep. CNVs in STH sheep breed were relevant to chest circumference and height of hip cross (p < 0.05). These results confirmed the relationship between CNV of TOP2B gene and growth traits in three sheep breeds, and provide a reliable reference for sheep breeding.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/60319]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Toremurat, Zhansaya,Ibrahim, Elsaeid Elnour,Huang, Yong-Zhen,et al. Copy number variations of TOP2B gene are associated with growth traits in Chinese sheep breeds[J]. ANIMAL BIOTECHNOLOGY,2020.
APA	Toremurat, Zhansaya.,Ibrahim, Elsaeid Elnour.,Huang, Yong-Zhen.,Lan, Xianyong.,Pi, Li.,...&Chen, Hong.(2020).Copy number variations of TOP2B gene are associated with growth traits in Chinese sheep breeds.ANIMAL BIOTECHNOLOGY.
MLA	Toremurat, Zhansaya,et al."Copy number variations of TOP2B gene are associated with growth traits in Chinese sheep breeds".ANIMAL BIOTECHNOLOGY (2020).