Effects of phycocyanin in modulating the intestinal microbiota of mice

doi:10.1002/mbo3.825

	Effects of phycocyanin in modulating the intestinal microbiota of mice
	Xie, Yuanyuan 1,2; Li, Wenjun 2; Zhu, Limeng 2,3; Zhai, Shixiang 2; Qin, Song 2; Du, Zhenning 1
刊名	MICROBIOLOGYOPEN
	2019-09-01
卷号	8 期号:9 页码:11
关键词	16S rRNA high-throughput sequencing intestinal barrier intestinal microbiota phycocyanin
ISSN号	2045-8827
DOI	10.1002/mbo3.825
英文摘要	The health-promoting effects of phycocyanin (PC) have become widely accepted over the last two decades. In this study, we investigated the effects of different doses of PC in modulating the intestinal microbiota and the intestinal barrier in mice. Six-week-old male C57BL/6 mice were treated with PC for 28 days. Fecal samples were collected before and after PC intervention, and the microbiota were analyzed by 16S rRNA high-throughput sequencing. Bacterial abundance and diversity increased after PC intervention. Saccharolytic bacteria of the families Lachnospiraceae and Ruminococcaceae, which can produce butyric acid, increased after PC treatment. The family Rikenellaceae, which contains hydrogen-producing bacteria, also increased after PC intervention. The PC treatment reduced intestinal permeability and increased the intestinal barrier function, as demonstrated by hematoxylin-eosin staining and reduced serum lipopolysaccharide levels. The modulating effects on the intestinal microbiota were more favorable in the low-dose PC group.
WOS关键词	OXIDATIVE STRESS ; DIET ; LACHNOSPIRACEAE ; SPECIALIZATION ; INFLAMMATION ; ANTIOXIDANT ; DIVERSITY ; BUTYRATE ; ECOLOGY
WOS研究方向	Microbiology
语种	英语
出版者	WILEY
WOS记录号	WOS:000485975100004
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/30881]
专题	中国科学院过程工程研究所
通讯作者	Qin, Song; Du, Zhenning
作者单位	1.Yantai Univ, Yantai, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xie, Yuanyuan,Li, Wenjun,Zhu, Limeng,et al. Effects of phycocyanin in modulating the intestinal microbiota of mice[J]. MICROBIOLOGYOPEN,2019,8(9):11.
APA	Xie, Yuanyuan,Li, Wenjun,Zhu, Limeng,Zhai, Shixiang,Qin, Song,&Du, Zhenning.(2019).Effects of phycocyanin in modulating the intestinal microbiota of mice.MICROBIOLOGYOPEN,8(9),11.
MLA	Xie, Yuanyuan,et al."Effects of phycocyanin in modulating the intestinal microbiota of mice".MICROBIOLOGYOPEN 8.9(2019):11.