Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy

doi:10.1016/j.matdes.2017.11.004

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	Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy
	Yang, Jinghai 1; Gao, Fei 1; Han, Donglai 2; Yang, Lili 1; Kong, Xiangwang 1; Wei, Maobin 1; Cao, Jian 1; Liu, Huilian 1; Wu, Zhitao 3; Pan, Guoyu3
刊名	MATERIALS & DESIGN
	2018-02-05
卷号	139 页码:172-180
关键词	Zinc-based nanoplatform pH-responsive Drug delivery Multifunction
ISSN号	0264-1275
DOI	10.1016/j.matdes.2017.11.004
文献子类	Article
英文摘要	Novel multifunctional ZnO@ (Fe3O4/ZnS:Mn2+) nanocomposites as a pH-responsive drug delivery system were designed and successfully synthesized by a self-assembling method. The as-prepared ZnO@(Fe3O4/ZnS:Mn2+) possess porous hollow structure with strong orange fluorescence and fastermagnetic response, which is beneficial for the functions of drug loading, fluorescence labeling and magnetic targeting simultaneously. Both in vitro and in vivo experiments testify that the ZnO@(Fe3O4/ZnS:Mn2+) nanocomposites own a good biocompatibility without obvious side effects on both cells and mice. After 24 days of treatment on the mice, ZnO@(Fe3O4/ZnS:Mn2+) nanocomposites greatly inhibited the tumor growth without causing both body weight change and any obvious pathological changes in major organs. The better antitumor efficacy than free DOX can be ascribed to both the accumulation of DOX-ZnO@(Fe3O4/ZnS:Mn2+) inside tumor and a sustained DOX release due to the dissociation of ZnO@(Fe3O4/ZnS:Mn2+) in acidic environment. (C) 2017 Elsevier Ltd. All rights reserved.
资助项目	National Programs for High Technology Research and Development of China (863)[2013AA032202] ; National Natural Science Foundation of China[21576111] ; National Natural Science Foundation of China[61378085] ; National Natural Science Foundation of China[61605059] ; National Natural Science Foundation of China[61405072] ; Program for the development of Science and Technology of Jilin Province[20150101180JC] ; Program for the development of Science and Technology of Jilin Province[20160101287JC]
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; ZNS QUANTUM DOTS ; OXIDE NANOPARTICLE ; DOXORUBICIN ; RELEASE ; LUMINESCENCE ; NANOCARRIERS ; CANCER ; NANOCRYSTALS ; NANOSPHERES
WOS研究方向	Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000423753200020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279914]
专题	药物安全性评价中心
通讯作者	Yang, Jinghai; Yang, Lili; Wei, Maobin
作者单位	1.Jilin Normal Univ, Key Lab Funct Mat Phys & Chem, Minist Educ, Changchun 130013, Jilin, Peoples R China; 2.Changchun Univ Sci & Technol, Sch Mat Sci & Engn, Changchun 130022, Jilin, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200000, Peoples R China
推荐引用方式 GB/T 7714	Yang, Jinghai,Gao, Fei,Han, Donglai,et al. Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy[J]. MATERIALS & DESIGN,2018,139:172-180.
APA	Yang, Jinghai.,Gao, Fei.,Han, Donglai.,Yang, Lili.,Kong, Xiangwang.,...&Pan, Guoyu.(2018).Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy.MATERIALS & DESIGN,139,172-180.
MLA	Yang, Jinghai,et al."Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy".MATERIALS & DESIGN 139(2018):172-180.