Canonical transient receptor potential 4 and its small molecule modulators

doi:10.1007/s11427-014-4772-5

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	Canonical transient receptor potential 4 and its small molecule modulators
	Fu Jie 1,3; Gao ZhaoBing1 ; Shen Bing 3; Zhu, Michael X.1,2
刊名	SCIENCE CHINA-LIFE SCIENCES
	2015-01
卷号	58 期号:1 页码:39-47
关键词	TRPC4 channel non-selective cation channel G protein coupled receptors small molecular modulators G proteins excitation contraction Ca2+ signaling
ISSN号	1674-7305
DOI	10.1007/s11427-014-4772-5
文献子类	Article
英文摘要	Canonical transient receptor potential 4 (TRPC4) forms non-selective cation channels that contribute to phospholipase C-dependent Ca2+ entry into cells following stimulation of G protein coupled receptors and receptor tyrosine kinases. Moreover, the channels are regulated by pertussis toxin-sensitive G(i/o) proteins, lipids, and various other signaling mechanisms. TRPC4-containing channels participate in the regulation of a variety of physiological functions, including excitability of both gastrointestinal smooth muscles and brain neurons. This review is to present recent advances in the understanding of physiology and development of small molecular modulators of TRPC4 channels.
资助项目	National Natural Science Foundation of China[81228021] ; US National Institutes of Health[DK081654]
WOS关键词	OPERATED CA2+ ENTRY ; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS ; NONSELECTIVE CATION CHANNELS ; ILEAL SMOOTH-MUSCLE ; TRPC CHANNELS ; CALCIUM-ENTRY ; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE ; SURFACE EXPRESSION ; INTERSTITIAL-CELLS ; ENDOTHELIAL-CELLS
WOS研究方向	Life Sciences & Biomedicine - Other Topics
语种	英语
CSCD记录号	CSCD:5386258
出版者	SCIENCE PRESS
WOS记录号	WOS:000347720800005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276773]
专题	神经药理学研究国际科学家工作站
通讯作者	Zhu, Michael X.
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Int Scientist Workstn Neuropharmacol, Shanghai 201203, Peoples R China; 2.Univ Texas Hlth Sci Ctr Houston, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA 3.Anhui Med Univ, Dept Physiol, Hefei 230032, Peoples R China;
推荐引用方式 GB/T 7714	Fu Jie,Gao ZhaoBing,Shen Bing,et al. Canonical transient receptor potential 4 and its small molecule modulators[J]. SCIENCE CHINA-LIFE SCIENCES,2015,58(1):39-47.
APA	Fu Jie,Gao ZhaoBing,Shen Bing,&Zhu, Michael X..(2015).Canonical transient receptor potential 4 and its small molecule modulators.SCIENCE CHINA-LIFE SCIENCES,58(1),39-47.
MLA	Fu Jie,et al."Canonical transient receptor potential 4 and its small molecule modulators".SCIENCE CHINA-LIFE SCIENCES 58.1(2015):39-47.