Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement

doi:10.1016/j.pbb.2016.01.010

	Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement
	Gong, Xiaokang 1; Yue, Kai 1; Ma, Baomiao 1; Xing, Junqiao 1; Gan, Yongping 2; Wang, Daisong 2; Jin, Guozhang1,3 ; Li, Chaoying 1
刊名	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
	2016-05
卷号	144 页码:67-72
关键词	Levo-tetrahydropalmatine Methamphetamine Dopamine Antagonist Self-administration Reinstatement
ISSN号	0091-3057
DOI	10.1016/j.pbb.2016.01.010
文献子类	Article
英文摘要	Despite the high prevalence of methamphetamine (METH) use, no FDA-approved pharmacological treatment is currently available for individuals with a METH addiction. Levo-tetrahydropalmatine (l-THP) is an alkaloid substance derived from corydalis and stephania that has been used in traditional Asian medicine for its analgesic, sedative and hypnotic properties. Previous pharmacological studies of l-THP indicated that it not only binds to D1 and D2 receptors but also has a low affinity for D3 receptors and may function as an antagonist. The unique pharmacological profile of l-THP suggests that it may have potential therapeutic effects on drug addiction; however, the effects of l-THP in individuals with METH addictions are largely unknown. In this study, we investigated the effects of l-THP on METH self-administration and METH-induced reinstatement. In our experiments, l-THP (1.25, 2.50 and 5.00 mg/kg, i.p.) decreased METH self-administration under the fixed-ratio 1 schedule. 1-THP (2.50 and 5.00 mg/kg, i.p) also prevented the METH-induced reinstatement of METH-seeking behaviors. Interestingly, l-THP (1.25 and 2.50 mg/kg, i.p) did not affect locomotor activity following METH injection (1 mg/kg) suggesting that the observed effects of l-THP (2.50 mg/kg) on METH-induced reinstatement were not due to motor impairments. Thus, l-THP (a natural, mixed dopamine (DA) receptor antagonist) attenuates METH self-administration and METH-induced reinstatement. (C) 2016 Published by Elsevier Inc.
资助项目	National Natural Science Foundation of China[81302762]
WOS关键词	PROGRESSIVE-RATIO SCHEDULES ; CUE-INDUCED REINSTATEMENT ; DRUG-SEEKING ; LOCOMOTOR SENSITIZATION ; NUCLEUS-ACCUMBENS ; COCAINE SEEKING ; CAUDATE-PUTAMEN ; PARTIAL AGONIST ; D-AMPHETAMINE ; D1
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000374798100010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276059]
专题	院士及顾问专家
通讯作者	Li, Chaoying
作者单位	1.Jianghan Univ, Wuhan Inst Biomed Sci, Wuhan 430056, Peoples R China; 2.Hubei Publ Secur Bur, Drug Prevent & Educ Ctr, Wuhan 430070, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201213, Peoples R China
推荐引用方式 GB/T 7714	Gong, Xiaokang,Yue, Kai,Ma, Baomiao,et al. Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2016,144:67-72.
APA	Gong, Xiaokang.,Yue, Kai.,Ma, Baomiao.,Xing, Junqiao.,Gan, Yongping.,...&Li, Chaoying.(2016).Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,144,67-72.
MLA	Gong, Xiaokang,et al."Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 144(2016):67-72.