Proteomic Assessment of Tanshinone II A Sodium Sulfonate on Doxorubicin Induced Nephropathy

doi:10.1142/S0192415X11008907

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	Proteomic Assessment of Tanshinone II A Sodium Sulfonate on Doxorubicin Induced Nephropathy
	Liu, Xuan 2,3; Wang, Yingchun 2; Ma, Chao 2; Zhang, Lin 2; Wu, Wanying2,3 ; Guan, Shuhong2 ; Yang, Min 2; Wang, Junchen 1; Jiang, Baohong2,3 ; Guo, De-An2
刊名	AMERICAN JOURNAL OF CHINESE MEDICINE
	2011
卷号	39 期号:2 页码:395-409
关键词	Doxorubicin Tanshinone II A Sodium Sulfonate Nephropathy
ISSN号	0192-415X
DOI	10.1142/S0192415X11008907
文献子类	Article
英文摘要	Although doxorubicin (DXR) is an important antineoplastic agent, the serious toxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. Our hypothesis is that tanshinone II A sodium sulfonate (TSNIIA-SS), which holds significant effects against oxidative stress, protects against DXR-induced nephropathy. Firstly, the antioxidative effects of TSNIIA-SS were confirmed using oxygen radicals absorbance capacities (ORAC) assay in vitro. Then, DXR nephropathy was induced by repeated DXR treatment and verified by kidney index (20.76 +/- 3.04 mg/mm versus 14.76 +/- 3.04 mg/mm, p < 0.001) and histochemical stain. The mice were randomized into three groups.Control group, DXR group and DXR-TSNIIA-SS group. TSNIIA-SS treatment not only improved DXR lesion identified by histochemical stain, but also regulated the expression of several proteins related with the cytoskeleton, oxidative stress and protein synthesis or degradation detected by two-dimensional electrophoresis (2-DE). These data have provided the evidence that TSNIIA-SS is a protective agent against DXR-induced nephropathy.
资助项目	National S&T major special project for new innovative drug[2009ZX09308-005] ; National S&T major special project for new innovative drug[2009ZX09102-122] ; National S&T major special project for new innovative drug[2009ZX090304-002] ; National S&T major special project for new innovative drug[2009ZX09311-001] ; National S&T major special project for new innovative drug[2009ZX09502-020] ; National S&T major special project for new innovative drug[2009ZxX09311-001] ; State Key Laboratory of Natural and Biomimetic Drugs[K20090209]
WOS关键词	MYOINOSITOL OXYGENASE ; OXIDATIVE STRESS ; PROTEIN ; EXPRESSION ; CARDIOTOXICITY ; SUBUNIT ; DANSHEN ; TISSUES ; KIDNEY ; INJURY
WOS研究方向	Integrative & Complementary Medicine ; General & Internal Medicine
语种	英语
出版者	WORLD SCIENTIFIC PUBL CO PTE LTD
WOS记录号	WOS:000289154800015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278634]
专题	上海中药现代化研究中心
通讯作者	Guo, De-An
作者单位	1.Tongji Univ, Dept Pathol, Dongfang Hosp, Shanghai 200120, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China;
推荐引用方式 GB/T 7714	Liu, Xuan,Wang, Yingchun,Ma, Chao,et al. Proteomic Assessment of Tanshinone II A Sodium Sulfonate on Doxorubicin Induced Nephropathy[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2011,39(2):395-409.
APA	Liu, Xuan.,Wang, Yingchun.,Ma, Chao.,Zhang, Lin.,Wu, Wanying.,...&Guo, De-An.(2011).Proteomic Assessment of Tanshinone II A Sodium Sulfonate on Doxorubicin Induced Nephropathy.AMERICAN JOURNAL OF CHINESE MEDICINE,39(2),395-409.
MLA	Liu, Xuan,et al."Proteomic Assessment of Tanshinone II A Sodium Sulfonate on Doxorubicin Induced Nephropathy".AMERICAN JOURNAL OF CHINESE MEDICINE 39.2(2011):395-409.