Thiamine hydrochloride (VB1)-catalyzed one-pot synthesis of (E)-N-benzylidene-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine derivatives

doi:10.1016/j.tet.2013.02.022

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	Thiamine hydrochloride (VB1)-catalyzed one-pot synthesis of (E)-N-benzylidene-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine derivatives
	Chen, Fanglei; Lei, Min; Hu, Lihong
刊名	TETRAHEDRON
	2013-04-08
卷号	69 期号:14 页码:2954-2960
关键词	Multi-component reaction Thiamine hydrochloride (VB1) Green chemistry 2-Aminobenzimidazole TMSCN
ISSN号	0040-4020
DOI	10.1016/j.tet.2013.02.022
文献子类	Article
英文摘要	An environmentally benign and efficient method has been developed for the synthesis of (E)-N-benzylidene-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine derivatives via a four-component reaction of 2-aminobenzimidazole, two molecules of aromatic aldehyde, and trimethylsilanecarbonitrile (TMSCN) in the presence of a catalytic amount of thiamine hydrochloride (VB1) in EtOH at reflux temperature. The advantages of this method are the use of an inexpensive and readily available catalyst, high yields, simple workup, and easy purification. (C) 2013 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2013ZX09508104] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2012ZX09301001-001] ; Chinese National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program'[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700]
WOS关键词	MANNICH-TYPE REACTION ; MULTICOMPONENT REACTIONS ; BIGINELLI REACTION ; 1,3-DICARBONYL COMPOUNDS ; PYRIMIDINE-DERIVATIVES ; BENZOIN CONDENSATION ; EFFICIENT SYNTHESIS ; UGI REACTION ; WATER ; 2-AMINOBENZIMIDAZOLE
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000316516500011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277657]
专题	上海中药现代化研究中心
通讯作者	Lei, Min
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chen, Fanglei,Lei, Min,Hu, Lihong. Thiamine hydrochloride (VB1)-catalyzed one-pot synthesis of (E)-N-benzylidene-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine derivatives[J]. TETRAHEDRON,2013,69(14):2954-2960.
APA	Chen, Fanglei,Lei, Min,&Hu, Lihong.(2013).Thiamine hydrochloride (VB1)-catalyzed one-pot synthesis of (E)-N-benzylidene-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine derivatives.TETRAHEDRON,69(14),2954-2960.
MLA	Chen, Fanglei,et al."Thiamine hydrochloride (VB1)-catalyzed one-pot synthesis of (E)-N-benzylidene-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine derivatives".TETRAHEDRON 69.14(2013):2954-2960.