Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats

doi:10.1016/j.jcma.2014.10.001

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	Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats
	Deng, Yanping 3; Zhang, Tingting 1,3; Teng, Fukang 1,3; Li, Defang 3; Xu, Feng 1; Cho, Kenka 2; Xu, Jinghua 1; Yin, Jun 1; Zhang, Li 1,3; Liu, Qian 1
刊名	JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
	2015-02
卷号	78 期号:2 页码:114-120
关键词	acute myocardial infarction ginsenoside Rb1 ginsenoside Rg1 Panax notoginseng salvianolic acid B Salvia miltiorrhiza
ISSN号	1726-4901
DOI	10.1016/j.jcma.2014.10.001
文献子类	Article
英文摘要	Background: The herb pair of Salvia miltiorrhiza and Panax notoginseng has widely been used for improving coronary and cerebral circulation in China. However, the exact contribution of the major active components of S. miltiorrhiza and P. notoginseng to cardioprotection is far from clear. In the present study, three representative ingredients, salvianolic acid B (SalB) from S. miltiorrhiza and ginsenoside Rg1 (Rg1) and ginsenoside Rb1 (Rb1) from P. notoginseng, were selected to elucidate the mechanism of the herb pair at the ingredient level. Methods: The purity of SalB, Rg1, and Rb1 was >99%, as detected by high-performance liquid chromatography. Acute myocardial infarction was introduced by ligation of the left anterior descending coronary artery near the main pulmonary artery. Cardiac contractility was detected through a Mikro-tipped catheter, and cardiac infarct size was determined using triphenyltetrazolium chloride stain. Results: The combination of SalB and Rg1, and not the combination of SalB and Rb1, improved heart contractility in rats with myocardial infarction. The different contributions of Rg1 and Rb1, in combination with SalB, to cardioprotection provides further direction to optimize and modernize the herbal medicines containing S. miltiorrhiza and P. notoginseng. Conclusion: The combination of SalB and Rg1 may provide potential protection against myocardial infarction. Copyright (C) 2014 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.
资助项目	National Science and Technology Major Project for "Key New Drug Creation and Manufacturing Program"[2013ZX09103002-024] ; National Natural Science Foundation of China[81173587] ; Shanghai Science and Technology Development Foundation[14401900900] ; 12th 5-Year National Science and Technology Support Program[2012BAI29B06] ; National High Technology Research and Development Program ("863" Program) of China[SS2013AA09002]
WOS关键词	PANAX-NOTOGINSENG ; FUFANG-DANSHEN ; MILTIORRHIZA ; ANGIOGENESIS ; MECHANISMS ; COMPONENTS ; SAPONINS ; QUALITY ; RADIX
WOS研究方向	General & Internal Medicine
语种	英语
出版者	ELSEVIER TAIWAN
WOS记录号	WOS:000351246200007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276647]
专题	上海中药现代化研究中心
通讯作者	Jiang, Baohong
作者单位	1.Shenyang Pharmaceut Univ, Shenyang, Peoples R China; 2.Takarazuka Univ Med & Hlth Care, Takarazuka, Hyogo, Japan 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Deng, Yanping,Zhang, Tingting,Teng, Fukang,et al. Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats[J]. JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,2015,78(2):114-120.
APA	Deng, Yanping.,Zhang, Tingting.,Teng, Fukang.,Li, Defang.,Xu, Feng.,...&Jiang, Baohong.(2015).Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats.JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,78(2),114-120.
MLA	Deng, Yanping,et al."Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats".JOURNAL OF THE CHINESE MEDICAL ASSOCIATION 78.2(2015):114-120.