Cytotoxic sesquiterpene lactone dimers isolated from Inula japonica

doi:10.1016/j.fitote.2015.01.011

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 上海中药现代化研究中心

	Cytotoxic sesquiterpene lactone dimers isolated from Inula japonica
	Xu, Xing-Yu; Sun, Peng; Guo, De-An; Liu, Xuan; Liu, Jun-Hua; Hu, Li-Hong
刊名	FITOTERAPIA
	2015-03
卷号	101 页码:218-223
关键词	Inula japonica Thunb Sesquiterpene lactone dimer Biomimetic transformation Cytotoxicity
ISSN号	0367-326X
DOI	10.1016/j.fitote.2015.01.011
文献子类	Article
英文摘要	Two new sesquiterpene lactone dimers, neojaponicone B (1) and inulanolide E (2) along with five known sesquiterpene lactone dimers (3-7, resp.) were isolated from the aerial parts of Inula japonica Thunb. The chemical structures of 1 and 2 were elucidated by detailed spectroscopic analysis. The relative configuration of 2 was confirmed by biomimetic transformation from the known sesquiterpene lactone dimer inulanolide A (3). The cytotoxicities of the isolated sesquiterpene lactone dimers were evaluated against 6T-CEM and Jurkat cell lines. All compounds showed potent cytotoxicities with IC50 value of 22-5.9 mu m. (C) 2015 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[81273397] ; National Natural Science Foundation of China[81402811] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] ; China Postdoctoral Science Foundation[2014M550255]
WOS关键词	A-D ; THUNB ; LINEARIIFOLIA ; CONSTITUENTS ; CELLS ; NO
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000352252700027
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276617]
专题	上海中药现代化研究中心
通讯作者	Liu, Jun-Hua
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Xu, Xing-Yu,Sun, Peng,Guo, De-An,et al. Cytotoxic sesquiterpene lactone dimers isolated from Inula japonica[J]. FITOTERAPIA,2015,101:218-223.
APA	Xu, Xing-Yu,Sun, Peng,Guo, De-An,Liu, Xuan,Liu, Jun-Hua,&Hu, Li-Hong.(2015).Cytotoxic sesquiterpene lactone dimers isolated from Inula japonica.FITOTERAPIA,101,218-223.
MLA	Xu, Xing-Yu,et al."Cytotoxic sesquiterpene lactone dimers isolated from Inula japonica".FITOTERAPIA 101(2015):218-223.