Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium

doi:10.1007/s00706-015-1449-0

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	Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium
	Shen, Sida; Chen, Yijia; Lei, Min; Hu, Lihong
刊名	MONATSHEFTE FUR CHEMIE
	2015-09
卷号	146 期号:9 页码:1571-1580
关键词	2-Cyanobenzaldehyde Isoindolin-1-imine Multi-component reactions Green chemistry
ISSN号	0026-9247
DOI	10.1007/s00706-015-1449-0
文献子类	Article
英文摘要	A catalyst-free, one-pot method has been developed for the synthesis of isoindolin-1-imine derivatives via cascade three-component condensation of 2-cyanobenzaldehyde, amine, and active methylene compound (1,3-dimethylbarbituric acid, Meldrum's acid, 5,5-dimethylcyclohexane-1,3-dione, and 1,3-cyclohexanedione). The efficient and convenient reaction provides the corresponding products from various substrates at room temperature in aqueous medium with excellent yields (90-98 %) via easy purification. The straightforward procedure is a valid contribution to the methodology for the synthesis of isoindolin-1-imine derivatives.
资助项目	National Natural Science Foundation of China[30925040] ; National Natural Science Foundation of China[81102329] ; National Natural Science Foundation of China[81273397] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2013ZX09508104] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2011ZX09307-002-03] ; Science Foundation of Shanghai[12XD1405700]
WOS关键词	NMDA RECEPTOR ANTAGONISTS ; KNOEVENAGEL CONDENSATION ; MELDRUMS ACID ; PART 2 ; ALDEHYDES ; 2-CYANOBENZALDEHYDE ; AMINES
WOS研究方向	Chemistry
语种	英语
出版者	SPRINGER WIEN
WOS记录号	WOS:000359272500021
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276427]
专题	上海中药现代化研究中心
通讯作者	Lei, Min
作者单位	Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Shen, Sida,Chen, Yijia,Lei, Min,et al. Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium[J]. MONATSHEFTE FUR CHEMIE,2015,146(9):1571-1580.
APA	Shen, Sida,Chen, Yijia,Lei, Min,&Hu, Lihong.(2015).Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium.MONATSHEFTE FUR CHEMIE,146(9),1571-1580.
MLA	Shen, Sida,et al."Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium".MONATSHEFTE FUR CHEMIE 146.9(2015):1571-1580.