New insights into the degradation mechanism of metal-organic frameworks drug carriers

doi:10.1038/s41598-017-13323-1

	New insights into the degradation mechanism of metal-organic frameworks drug carriers
	Li, X.2; Lachmanski, L.5; Safi, S.5; Sene, S.1; Serre, C.1; Greneche, J. M.4; Zhang, J.3 ; Gref, R.2
刊名	SCIENTIFIC REPORTS
	2017-10-13
卷号	7
ISSN号	2045-2322
DOI	10.1038/s41598-017-13323-1
文献子类	Article
英文摘要	A versatile method based on Raman microscopy was developed to follow the degradation of iron carboxylate Metal Organic Framework (MOF) nano-or micro-particles in simulated body fluid (phosphate buffer). The analysis of both the morphology and chemical composition of individual particles, including observation at different regions on the same particle, evidenced the formation of a sharp erosion front during particle degradation. Interestingly, this front separated an intact non eroded crystalline core from an amorphous shell made of an inorganic network. According to Mossbauer spectrometry investigations, the shell consists essentially of iron phosphates. Noteworthy, neither drug loading nor surface modification affected the integrity of the tridimensional MOF network. These findings could be of interest in the further development of next generations of MOF drug carriers.
资助项目	European Marie Curie network CycloN Hit[608407] ; French National Research Agency (ANR)[ANR-14-CE08-0017] ; ANR (Labex NanoSaclay)[ANR-10-LABX-0035] ; China scholarship council[201408330166] ; National Natural Science Foundation of China[81430087]
WOS关键词	HYDROPHILIC ANTICANCER DRUG ; MIL-100(FE) NANOPARTICLES ; DELIVERY ; ENCAPSULATION ; MOF ; SITES ; TEMPERATURE ; ADSORPTION ; PLATFORM ; SIZE
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000412956900032
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272452]
专题	科研条件处
通讯作者	Gref, R.
作者单位	1.PSL Res Univ, Inst Mat Poreux Paris, FRE CNRS ENS ESPCI 2000, F-75005 Paris, France; 2.Univ Paris Saclay, Univ Paris Sud, Inst Sci Mol Orsay, UMR CNRS 8214, F-91405 Orsay, France; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Le Mans Univ, IMMM, UMR CNRS 6283, F-72085 Le Mans, France; 5.Malvern Instruments, 30 Rue Jean Rostand, F-91405 Orsay, France;
推荐引用方式 GB/T 7714	Li, X.,Lachmanski, L.,Safi, S.,et al. New insights into the degradation mechanism of metal-organic frameworks drug carriers[J]. SCIENTIFIC REPORTS,2017,7.
APA	Li, X..,Lachmanski, L..,Safi, S..,Sene, S..,Serre, C..,...&Gref, R..(2017).New insights into the degradation mechanism of metal-organic frameworks drug carriers.SCIENTIFIC REPORTS,7.
MLA	Li, X.,et al."New insights into the degradation mechanism of metal-organic frameworks drug carriers".SCIENTIFIC REPORTS 7(2017).