L-stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates methamphetamine self-administration in rats

doi:10.4028/www.scientific.net/AMR.998-999.169

	L-stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates methamphetamine self-administration in rats
	Yue, Kai 3; Ma, Bao Miao 3; Xing, Jun Qiao 3; Gong, Xiao Kang 3; Ru, Qin 3; Chen, Lin 3; Xiong, Qi 3; Tian, Xiang 3; Liu, Lu 3; Gan, Yong Qing 2
	2014
卷号	998-999
DOI	10.4028/www.scientific.net/AMR.998-999.169
页码	169-172
英文摘要	Given the problems associated with the escalation in methamphetamine (METH) use, the identification of more effective treatment strategies is essential. l-stepholidine (l-SPD) is an alkaloid extract of the Chinese herb Stephania intermedia with dopamine D1 receptor partial agonistic and D2 receptor antagonistic dual actions. The unique pharmacological profile of l-SPD suggests that l-SPD may be effective for the treatment of METH addiction. The aim of this study was to characterize the effect of l-SPD on METH self-administration on a fixed-ratio 1 schedule. We found that 5 and 10 mg/kg of l-SPD attenuated METH self-administration behavior. These results demonstrate that l-SPD which possesses dual actions on dopamine D1 and D2 receptors, attenuates METH self-administration on a fixed-ratio 1 schedule.
会议录	Advanced Materials Research
会议录出版者	Trans Tech Publications Ltd
文献子类	Proceedings Paper
语种	英语
内容类型	会议论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266852]
专题	院士及顾问专家
通讯作者	Li, Chao Ying
作者单位	1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201213, China 2.Drug Prevention and Education Center, Hubei Public Security Bureau, Wuhan 430070, China; 3.Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China;
推荐引用方式 GB/T 7714	Yue, Kai,Ma, Bao Miao,Xing, Jun Qiao,et al. L-stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates methamphetamine self-administration in rats[C]. 见:.