L-stepholidine blocks methamphetamine-induced locomotor sensitization in mice

doi:10.4028/www.scientific.net/AMR.998-999.156

	L-stepholidine blocks methamphetamine-induced locomotor sensitization in mice
	Ma, Bao Miao 3; Yue, Kai 3; Xing, Jun Qiao 3; Gong, Xiao Kang 3; Ru, Qin 3; Chen, Lin 3; Xiong, Qi 3; Tian, Xiang 3; Liu, Lu 3; Gan, Yong Qing 1
	2014
卷号	998-999
DOI	10.4028/www.scientific.net/AMR.998-999.156
页码	156-159
英文摘要	Repeating administration of methamphetamine (METH) can result in locomotor sensitization, a progressive increase in their psychomotor activating effects. l-Stepholidine (l-SPD), an alkaloid extract of the Chinese herb Stephania intermedia, is the first compound known to exhibit mixed dopamine D1 receptor agonist/D2 antagonist properties and is a potential medication for the treatment of drug addiction. Therefore, the effects of l-SPD on the hyperactivity, development and expression of METH-induced locomotor sensitization were investigated. The results indicated that l-SPD dose-dependently inhibited hyperlocomotion induced by acute METH and prevented the sensitized motor behavior induced by chronic METH administration. l-SPD likely acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of METH addiction.
会议录	Advanced Materials Research
会议录出版者	Trans Tech Publications Ltd
文献子类	Proceedings Paper
语种	英语
内容类型	会议论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266846]
专题	院士及顾问专家
通讯作者	Li, Chao Ying
作者单位	1.Drug Prevention and Education Center, Hubei Public Security Bureau, Wuhan 430070, China; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201213, China 3.Wuhan Institutes of Biomedical Sciences, Jianghan University, Wuhan 430056, China;
推荐引用方式 GB/T 7714	Ma, Bao Miao,Yue, Kai,Xing, Jun Qiao,et al. L-stepholidine blocks methamphetamine-induced locomotor sensitization in mice[C]. 见:.