Comparative Analysis of Ultrafine Granular Powder and Decoction Pieces of Salvia miltiorrhiza by UPLC-UV-MSn Combined with Statistical Analysis

doi:10.1055/s-0042-120543

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	Comparative Analysis of Ultrafine Granular Powder and Decoction Pieces of Salvia miltiorrhiza by UPLC-UV-MSn Combined with Statistical Analysis
	Shen, Yao 2; Hou, Jinjun2 ; Deng, Wen 1; Feng, Zijin 2; Yang, Min 2; Cheng, Jinle 1; Wu, Wanying2 ; Guo, De-an2
刊名	PLANTA MEDICA
	2017-04
卷号	83 期号:6 页码:557-564
关键词	chemical profiles Salvia miltiorrhiza (Fam. Labiatae) statistical analysis ultrafine granular powder
ISSN号	0032-0943
DOI	10.1055/s-0042-120543
文献子类	Article
英文摘要	Salvia miltiorrhiza is one of the most used herbal medicines for the treatment of a wide range of diseases in China. Decoction pieces and Chinese patent medicines from S. miltiorrhiza are the two main types of products used by patients. Other relatively new products of S. miltiorrhiza, like injections and ultrafine granular powder (D90 < 45 mu m before granulation), are also increasingly used nowadays. With the growing usage of new products of S. miltiorrhiza, their chemical components and pharmacological effects, compared to the traditional decoction pieces, are attracting attention. In this work, the chemical profiles of two types of products from S. miltiorrhiza (one is traditional "decoction pieces", the other is modern "ultrafine granular powder") were compared via similarity analysis and discriminated via multivariate analysis, e.g., hierarchical cluster analysis, principal component analysis, and partial least squares discrimination analysis. A new adamantane stationary phase column was used to establish informative chemical profiles of them. The mean similarity correlation coefficient (>0.987) revealed that ultrafine granular powder and decoction pieces of S. miltiorrhiza were consistent between each other and stable between different batches. Two types of S. miltiorrhiza products were clearly resolved from each other by hierarchical cluster analysis, principal component analysis, and partial least squares discrimination analysis. Compounds responsible for the discrimination results were further characterized by ESI-MS/MS. Eventually, 62 compounds selected as characteristic markers for evaluation were characterized or tentatively characterized. This result will facilitate the further comparison of these two types of S. miltiorrhiza products in pharmacology and pharmacokinetics.
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; FLIGHT MASS-SPECTROMETRY ; DIODE-ARRAY DETECTION ; QUALITY-CONTROL ; PHENOLIC-ACIDS ; CHEMICAL FINGERPRINT ; HPLC-DAD ; DANSHEN ; ROOTS ; IDENTIFICATION
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000399325400008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272723]
专题	上海中药现代化研究中心
通讯作者	Cheng, Jinle; Wu, Wanying
作者单位	1.Key Lab Technol Breaking Cell Wall & Applicat Chi, Kangtai Rd 3, Guangzhou 528437, Guangdong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, Haike Rd 501, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Shen, Yao,Hou, Jinjun,Deng, Wen,et al. Comparative Analysis of Ultrafine Granular Powder and Decoction Pieces of Salvia miltiorrhiza by UPLC-UV-MSn Combined with Statistical Analysis[J]. PLANTA MEDICA,2017,83(6):557-564.
APA	Shen, Yao.,Hou, Jinjun.,Deng, Wen.,Feng, Zijin.,Yang, Min.,...&Guo, De-an.(2017).Comparative Analysis of Ultrafine Granular Powder and Decoction Pieces of Salvia miltiorrhiza by UPLC-UV-MSn Combined with Statistical Analysis.PLANTA MEDICA,83(6),557-564.
MLA	Shen, Yao,et al."Comparative Analysis of Ultrafine Granular Powder and Decoction Pieces of Salvia miltiorrhiza by UPLC-UV-MSn Combined with Statistical Analysis".PLANTA MEDICA 83.6(2017):557-564.