Biofunctionalization of beta-cyclodextrin nanosponges using cholesterol

doi:10.1016/j.carbpol.2018.02.044

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Biofunctionalization of beta-cyclodextrin nanosponges using cholesterol
	Singh, Parbeen 1,2; Ren, Xiaohong 1; Guo, Tao 1; Wu, Li 1; Shakya, Shailendra 1,2; He, Yaping 1,2; Wang, Caifen 1; Maharjan, Abi 1,2; Singh, Vikramjeet 1; Zhang, Jiwen1,2
刊名	CARBOHYDRATE POLYMERS
	2018-06-15
卷号	190 页码:23-30
关键词	Biofunctionalization beta-CD nanosponge Cholesterol Cellular uptake
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2018.02.044
文献子类	Article
英文摘要	Cyclodextrins nanosponges (CD-NSPs) are highly microporous crosslinked polymers with potential applications in the delivery of small and macro-molecular therapeutic agents. Despite the potent host-guest inclusion property, their inherent lack of cellular binding ability has limited applications in drug delivery. Herein, we functionalized the surface of beta-cyclodextrin nanosponge (beta-CD-NSP) with cholesterol, which is endogenous physiological molecules, widely distributed in all cells, and responsible for cell interactions and protein binding. The surface grafting of synthesized beta-CD-NSP was confirmed with spectroscopic, microscopic, thermogravimetric, and chromatographic techniques. Moreover, beta-CD-NSP was found to be safe in cytotoxicity assay. Doxorubicin (Dox) was selected as a model drug for drug adsorption study of cholesterol hydrogen succinate (CHS) grafted beta-CD-NSP. The cellular uptake of NSP was found to be enhanced after CHS modification confirmed by confocal laser scanning microscopy (CLSM). Thus, proposed CHS modified beta-CD-NSP system could be used as a site-specific drug delivery carrier.
资助项目	National Natural Science Foundation of China[81430087] ; National Science and Technology Major Project[2017ZX09101001-006] ; CAS-TWAS Presidential Fellowship Program[00000000]
WOS关键词	DRUG-DELIVERY ; BIOMEDICAL APPLICATIONS ; SUPRAMOLECULAR SYSTEMS ; IN-VITRO ; CD-MOF ; NANOPARTICLES ; CANCER ; RESISTANT ; COPOLYMER ; MEMBRANES
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000429425500003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279705]
专题	药物制剂研究中心
通讯作者	Singh, Vikramjeet; Zhang, Jiwen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Singh, Parbeen,Ren, Xiaohong,Guo, Tao,et al. Biofunctionalization of beta-cyclodextrin nanosponges using cholesterol[J]. CARBOHYDRATE POLYMERS,2018,190:23-30.
APA	Singh, Parbeen.,Ren, Xiaohong.,Guo, Tao.,Wu, Li.,Shakya, Shailendra.,...&Zhang, Jiwen.(2018).Biofunctionalization of beta-cyclodextrin nanosponges using cholesterol.CARBOHYDRATE POLYMERS,190,23-30.
MLA	Singh, Parbeen,et al."Biofunctionalization of beta-cyclodextrin nanosponges using cholesterol".CARBOHYDRATE POLYMERS 190(2018):23-30.