Natural Brain Penetration Enhancer-Modified Albumin Nanoparticles for Glioma Targeting Delivery

doi:10.1021/acsami.8b11782

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Natural Brain Penetration Enhancer-Modified Albumin Nanoparticles for Glioma Targeting Delivery
	Liang, Jianming 1,2,3,5; Gao, Caifang 1,3,5; Zhu, Ying 2; Ling, Chengli 6; Wang, Qi 2; Huang, Yongzhuo4 ; Qin, Jing 1,3; Wang, Jue 1,3; Lu, Weigen 5; Wang, Jianxin 1,2,3
刊名	ACS APPLIED MATERIALS & INTERFACES
	2018-09-12
卷号	10 期号:36 页码:30201-30213
关键词	brain penetration enhancer menthol glioma brain permeability BBB-disrupting pineal gland
ISSN号	1944-8244
DOI	10.1021/acsami.8b11782
文献子类	Article
英文摘要	The unsatisfactory therapeutic outcome for glioma is mainly due to the poor blood-brain barrier (BBB) permeability and inefficient accumulation in the glioma area of chemotherapeutic agents. The existing drug delivery strategies can increase drug transport to the brain but are restricted by side effects and/or poor delivery efficiency. In this study, potent brain penetration enhancers were screened from the active components of aromatic resuscitation drugs used in traditional Chinese medicine. A novel glioma-targeting system based on enhancer-modified albumin nanoparticles was developed to safely and efficiently deliver drugs to the glioma regions in the brain. The nanoparticles improved the transport of nanoparticles across brain capillary endothelial cell (BCEC) monolayer by increasing endocytosis in endothelial cells and causing BBB disruption. In vivo imaging studies demonstrated that the systems could enter the brain and subsequently accumulate in glioma cells with a much higher targeting efficiency than that of transferrin-modified albumin nanoparticles. Of note, the nanoparticles could be captured and penetrate through endothelial cells fenestrae in pineal gland, which is suggestive of an effective way to deliver a nanosystem to the brain by bypassing the BBB. The nanoparticles showed good biocompatibility and negligible cytotoxicity. The results reveal an efficient and safe strategy for brain drug delivery in glioma therapy.
资助项目	National Natural Science Foundation of China[81573616] ; National Natural Science Foundation of China[81690263] ; National Natural Science Foundation of China[81773911] ; Development Project of Shanghai Peak Disciplines-Integrated Medicine[20150407]
WOS关键词	BLOOD-BRAIN ; DRUG-DELIVERY ; CO-DELIVERY ; CAPILLARY-PERMEABILITY ; PINEAL-GLAND ; IN-VIVO ; BARRIER ; BORNEOL ; OCCLUDIN ; FLOW
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000444793000023
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279580]
专题	药物制剂研究中心
通讯作者	Lu, Weigen; Wang, Jianxin
作者单位	1.Minist Educ, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China; 2.Guangzhou Univ Chinese Med, Guangzhou 510006, Guangdong, Peoples R China; 3.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 5.China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, Shanghai 201203, PR, Peoples R China; 6.Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China
推荐引用方式 GB/T 7714	Liang, Jianming,Gao, Caifang,Zhu, Ying,et al. Natural Brain Penetration Enhancer-Modified Albumin Nanoparticles for Glioma Targeting Delivery[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(36):30201-30213.
APA	Liang, Jianming.,Gao, Caifang.,Zhu, Ying.,Ling, Chengli.,Wang, Qi.,...&Wang, Jianxin.(2018).Natural Brain Penetration Enhancer-Modified Albumin Nanoparticles for Glioma Targeting Delivery.ACS APPLIED MATERIALS & INTERFACES,10(36),30201-30213.
MLA	Liang, Jianming,et al."Natural Brain Penetration Enhancer-Modified Albumin Nanoparticles for Glioma Targeting Delivery".ACS APPLIED MATERIALS & INTERFACES 10.36(2018):30201-30213.