Rapid and sensitive assay for trantinterol, a novel beta(2)-adrenoceptor agonist, in human plasma using liquid chromatography-tandem mass spectrometry

doi:10.1016/j.jpba.2009.01.012

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	Rapid and sensitive assay for trantinterol, a novel beta(2)-adrenoceptor agonist, in human plasma using liquid chromatography-tandem mass spectrometry
	Sun, Yantong 2; Liu, Mingyuan 2,4; Zhang, Jiwen1 ; Jiang, Yao 2; Yu, Weisong 2; Fawcett, John Paul 3; Gu, Jingkai 2
刊名	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
	2009-05-01
卷号	49 期号:4 页码:1056-1059
关键词	Trantinterol beta(2)-Adrenoceptor agonist Pharmacokinetics LC-MS/MS Plasma
ISSN号	0731-7085
DOI	10.1016/j.jpba.2009.01.012
文献子类	Article
英文摘要	A rapid and sensitive assay for trantinterol, a novel beta(2)-adrenoceptor agonist, in human plasma has been developed. Samples containing the analyte and internal standard, clenbuterol, were analyzed by liquid chromatography-tandem mass spectrometry after liquid-liquid extraction with diethyl ether:dichloromethane (60:40, v/v). Separation was performed on a Venusil MP C18 column (50 mm x 4.6 mm, 5 mu m) using methanol:1% formic acid (50:50, v/v) as mobile phase and monitored by multiple reaction monitoring of the precursor-to-product ion transitions of trantinterol at m/Z 311.2 -> 238.1 and clenbuterol at m/z 277.2 -> 203.1. The total run time was only 1.5 min and the method was linear over the concentration range 1-1000 pg/mL with a lower limit of quantitation of 1 pg/mL. Intra- and inter-day precisions (relative standard deviation) were below 7% and 12%, respectively, with accuracy (relative error) below 8%. The method was successfully applied to a pharmacokinetic study involving oral administration of a 50 mu g trantinterol tablet to healthy volunteers. (C) 2009 Elsevier B.V. All rights reserved.
WOS关键词	CAPILLARY GAS-CHROMATOGRAPHY ; TULOBUTEROL ; BETA(2)-AGONISTS ; CLENBUTEROL ; SALBUTAMOL ; RABBITS ; URINE
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000265046200029
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279258]
专题	药物制剂研究中心
通讯作者	Gu, Jingkai
作者单位	1.Chinese Acad Sci, Shanghai Inst Met Med, Shanghai 201203, Peoples R China; 2.Jilin Univ, Coll Life Sci, Res Ctr Drug Metab, Changchun 130021, Peoples R China; 3.Univ Otago, Sch Pharm, Dunedin, New Zealand 4.Jiamusi Univ, Sch Basic Med Sci, Dept Pharmacol, Jiamusi 154007, Peoples R China;
推荐引用方式 GB/T 7714	Sun, Yantong,Liu, Mingyuan,Zhang, Jiwen,et al. Rapid and sensitive assay for trantinterol, a novel beta(2)-adrenoceptor agonist, in human plasma using liquid chromatography-tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2009,49(4):1056-1059.
APA	Sun, Yantong.,Liu, Mingyuan.,Zhang, Jiwen.,Jiang, Yao.,Yu, Weisong.,...&Gu, Jingkai.(2009).Rapid and sensitive assay for trantinterol, a novel beta(2)-adrenoceptor agonist, in human plasma using liquid chromatography-tandem mass spectrometry.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,49(4),1056-1059.
MLA	Sun, Yantong,et al."Rapid and sensitive assay for trantinterol, a novel beta(2)-adrenoceptor agonist, in human plasma using liquid chromatography-tandem mass spectrometry".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 49.4(2009):1056-1059.