Multifunctional Graphene Oxide-based Triple Stimuli-Responsive Nanotheranostics

doi:10.1002/adfm.201400221

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Multifunctional Graphene Oxide-based Triple Stimuli-Responsive Nanotheranostics
	Chen, Yu 4; Xu, Pengfei 3; Shu, Zhu 4; Wu, Meiying 4; Wang, Lianzhou 1,2; Zhang, Shengjian 5; Zheng, Yuanyi 6; Chen, Hangrong 4; Wang, Jin 4; Li, Yaping3
刊名	ADVANCED FUNCTIONAL MATERIALS
	2014-07-23
卷号	24 期号:28 页码:4386-4396
ISSN号	1616-301X
DOI	10.1002/adfm.201400221
文献子类	Article
英文摘要	Construction of multifunctional stimuli-responsive nanosystems intelligently responsive to inner physiological and/or external irradiations based on nano-biotechnology can enable the on-demand drug release and improved diagnostic imaging to mitigate the side-effects of anticancer drugs and enhance the diagnostic/therapeutic outcome simultaneously. Here, a triple-functional stimuli-responsive nanosystem based on the co-integration of superparamagnetic Fe3O4 and paramagnetic MnOx nanoparticles (NPs) onto exfoliated graphene oxide (GO) nanosheets by a novel and efficient double redox strategy (DRS) is reported. Aromatic anticancer drug molecules can interact with GO nanosheets through supramolecular pi stacking to achieve high drug loading capacity and pH-responsive drug releasing performance. The integrated MnOx NPs can disintegrate in mild acidic and reduction environment to realize the highly efficient pH-responsive and reduction-triggered T-1-weighted magnetic resonance imaging (MRI). Superparamagnetic Fe3O4 NPs can not only function as the T-2-weighted contrast agents for MRI, but also response to the external magnetic field for magnetic hyperthermia against cancer. Importantly, the constructed biocompatible GO-based nanoplatform can inhibit the metastasis of cancer cells by downregulating the expression of metastasis-related proteins, and anticancer drug-loaded carrier can significantly reverse the multidrug resistance (MDR) of cancer cells.
资助项目	National Nature Science Foundation of China[51302293] ; National Nature Science Foundation of China[51132009] ; National Nature Science Foundation of China[51072212] ; National Nature Science Foundation of China[81270047] ; National Nature Science Foundation of China[21177137] ; National Basic Research Program of China (973 Program)[2011CB707905] ; National Basic Research Program of China (973 Program)[2010CB934000] ; China National Funds for Distinguished Young Scientists[51225202] ; Natural Science Foundation of Shanghai[13ZR1463500] ; Nano Special Program of the Science and Technology Commission of Shanghai[11nm0506500] ; Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures[SKL201203]
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; NEAR-INFRARED ABSORBENCY ; PHOTOTHERMAL THERAPY ; CANCER-CELLS ; DRUG-DELIVERY ; MAGNETIC NANOPARTICLES ; MANGANESE OXIDE ; IN-SITU ; RELEASE ; METASTASIS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000339713900001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276978]
专题	药物制剂研究中心
通讯作者	Chen, Yu
作者单位	1.Univ Queensland, AIBN, St Lucia, Qld 4072, Australia; 2.Univ Queensland, Sch Chem Engn, ARC Ctr Excellence Funct Nanomat, St Lucia, Qld 4072, Australia; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Ceram, State Lab High Performance Ceram & Superfine Micr, Shanghai 200050, Peoples R China; 5.Fudan Univ, Shanghai Canc Hosp, Dept Radiol, Shanghai 200032, Peoples R China; 6.Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yu,Xu, Pengfei,Shu, Zhu,et al. Multifunctional Graphene Oxide-based Triple Stimuli-Responsive Nanotheranostics[J]. ADVANCED FUNCTIONAL MATERIALS,2014,24(28):4386-4396.
APA	Chen, Yu.,Xu, Pengfei.,Shu, Zhu.,Wu, Meiying.,Wang, Lianzhou.,...&Shi, Jianlin.(2014).Multifunctional Graphene Oxide-based Triple Stimuli-Responsive Nanotheranostics.ADVANCED FUNCTIONAL MATERIALS,24(28),4386-4396.
MLA	Chen, Yu,et al."Multifunctional Graphene Oxide-based Triple Stimuli-Responsive Nanotheranostics".ADVANCED FUNCTIONAL MATERIALS 24.28(2014):4386-4396.