Mutagenicity tests on epristeride in vitro and in vivo

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	Mutagenicity tests on epristeride in vitro and in vivo
	Wang, XL; Zhen, WJ; Wu, HY; Feng, J; Tu, ZH
刊名	ACTA PHARMACOLOGICA SINICA
	1998-11
卷号	19 期号:6 页码:569-572
关键词	epristeride mutagenicity tests chromosome aberrations micronucleus tests sperm count
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To evaluate the genetic effects of epristeride (Epr), a new prospective drug for treating benign prostatic hyperplasia. METHODS: 1) Assaying reverse mutation in histidine nutritional deficiency strain of Salmonella typhimurium 2) detecting chromosome aberrations in Chinese hamster lung cells (CHL); 3) micronucleus assays of mouse bone marrow; 4) counting sperm shape abnormalities 35 d after first ig Epr. RESULTS: 1) The reverse mutation happened at almost the same rate of the negative control. Epr did not induce bacterial mutation. 2) In vitro, the rates of aberration were all below 3%, thus Epr did not induce chromosome damage in CHL. 3) Micronucleated polychromatic erythroblasts (PCE) were not apparently more than those of sovent control, Epr did not induce the formation of micronuclei in PCE. 4) With Epr 818, 682, and 341 mg . kg(-1), the head abnormalities of sperms were 5.3% +/- 2.7%, 5.3% +/- 1.9%, and 5.2% +/- 1.2%, respectively. CONCLUSION: No genetic toxicity of Epr was detected.
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000076914200018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274794]
专题	药物制剂研究中心药物安全性评价中心
通讯作者	Tu, ZH
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Wang, XL,Zhen, WJ,Wu, HY,et al. Mutagenicity tests on epristeride in vitro and in vivo[J]. ACTA PHARMACOLOGICA SINICA,1998,19(6):569-572.
APA	Wang, XL,Zhen, WJ,Wu, HY,Feng, J,&Tu, ZH.(1998).Mutagenicity tests on epristeride in vitro and in vivo.ACTA PHARMACOLOGICA SINICA,19(6),569-572.
MLA	Wang, XL,et al."Mutagenicity tests on epristeride in vitro and in vivo".ACTA PHARMACOLOGICA SINICA 19.6(1998):569-572.