Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation

doi:10.1038/srep46517

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation
	Peng, Tingting 2; Zhang, Xuejuan 2; Huang, Ying 2; Zhao, Ziyu 2; Liao, Qiuying 2; Xu, Jing 2; Huang, Zhengwei 2; Zhang, Jiwen3 ; Wu, Chuan-yu 1; Pan, Xin 2,4
刊名	SCIENTIFIC REPORTS
	2017-05-02
卷号	7
ISSN号	2045-2322
DOI	10.1038/srep46517
文献子类	Article
英文摘要	An optimum carrier rugosity is essential to achieve a satisfying drug deposition efficiency for the carrier based dry powder inhalation (DPI). Therefore, a non-organic spray drying technique was firstly used to prepare nanoporous mannitol with small asperities to enhance the DPI aerosolization performance. Ammonium carbonate was used as a pore-forming agent since it decomposed with volatile during preparation. It was found that only the porous structure, and hence the specific surface area and carrier density were changed at different ammonium carbonate concentration. Furthermore, the carrier density was used as an indication of porosity to correlate with drug aerosolization. A good correlation between the carrier density and fine particle fraction (FPF) (r(2)=0.9579) was established, suggesting that the deposition efficiency increased with the decreased carrier density. Nanoporous mannitol with a mean pore size of about 6 nm exhibited 0.24-fold carrier density while 2.16-fold FPF value of the nonporous mannitol. The enhanced deposition efficiency was further confirmed from the pharmacokinetic studies since the nanoporous mannitol exhibited a significantly higher AUC(0-8h) value than the nonporous mannitol and commercial product Pulmicort. Therefore, surface modification by preparing nanoporous carrier through non-organic spray drying showed to be a facile approach to enhance the DPI aerosolization performance.
资助项目	National Science Foundation of China[81673375] ; Sun Yat-Sen University[16ykpy23] ; Innovative Scientic Research Team Introducing Project of Zhongshan City[2015-224]
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; INHALER FORMULATIONS ; DRIED MANNITOL ; DRUG-DELIVERY ; PARTICLE-SIZE ; LACTOSE ; MORPHOLOGY ; MICROPARTICLES ; AEROSOLISATION ; BUDESONIDE
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000400452100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272673]
专题	药物制剂研究中心
通讯作者	Pan, Xin; Wu, Chuanbin
作者单位	1.Univ Surrey, Dept Chem & Proc Engn, Guildford GU2 7XH, Surrey, England; 2.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Zhongshan WanYuan New Drug R&D Co Ltd, Zhongshan City 528451, Peoples R China; 5.Guangdong Res Ctr Drug Delivery Syst, Guangzhou 510006, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Peng, Tingting,Zhang, Xuejuan,Huang, Ying,et al. Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation[J]. SCIENTIFIC REPORTS,2017,7.
APA	Peng, Tingting.,Zhang, Xuejuan.,Huang, Ying.,Zhao, Ziyu.,Liao, Qiuying.,...&Wu, Chuanbin.(2017).Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation.SCIENTIFIC REPORTS,7.
MLA	Peng, Tingting,et al."Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation".SCIENTIFIC REPORTS 7(2017).