A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy

doi:10.1039/c7py00882a

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy
	Pan, Zhenzhen 1,4,5; Kang, Xuejia 1,5; Zeng, Yuaner 1; Zhang, Wenyuan 5; Peng, Huige 5; Wang, Jinyu 3,5; Huang, Wei 5; Wang, Huiyuan5 ; Shen, Youqing 2; Huang, Yongzhuo5
刊名	POLYMER CHEMISTRY
	2017-09-21
卷号	8 期号:35 页码:5275-5285
ISSN号	1759-9954
DOI	10.1039/c7py00882a
文献子类	Article
英文摘要	Polyethylenimine (PEI) is the most widely applied polymeric vector in gene delivery. However, its therapeutic application is hampered by the high cytotoxicity and poor in vivo transfection efficiency. We constructed a mannosylated, bioreducible hybrid of low-molecular-weight PEI and cell-penetrating peptide (termed Man-PEI5k-CPP) as a vector to deliver plasmid TRAIL (pTRAIL) for colorectal cancer treatment. We discovered that the colon cancer cells overexpressed mannose receptors (MR). With the combined functions of the tumor-targeting ligand and the CPP, the Man-PEI5k-CPP not only increased the cellular uptake efficiency, but also improved the efficiency of transfection, thus yielding enhanced inhibition efficacy on HCT116 human colon cancer cells, compared to the conventional PEI25k. The animal studies further confirmed the treatment success of Man-PEI5k-CPP/pTRAIL in the mice bearing xenografted HCT116 tumors and showed minimal systemic toxicity.
资助项目	973 Program, China[2014CB931900] ; NFSC[81402883] ; NFSC[81673382] ; NFSC[81521005] ; NFSC[81422048] ; Scientific Research and Equipment Development Project[YZ201437] ; Youth Innovation Promotion Association[00000000]
WOS关键词	APOPTOSIS-INDUCING LIGAND ; PRODRUG-LIKE ; NANOPARTICLES ; REVERSAL ; CHITOSAN ; PROTEIN ; VECTOR
WOS研究方向	Polymer Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000411268700003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272480]
专题	药物制剂研究中心
通讯作者	Wang, Huiyuan; Huang, Yongzhuo
作者单位	1.Guangzhou Univ Chinese Med, Guangzhou 501450, Peoples R China; 2.Zhejiang Univ, Coll Chem & Biol Engn, Hangzhou 310027, Zhejiang, Peoples R China 3.Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China; 4.Guangxi Univ Chinese Med, Fac Pharm, Guangxi Coll & Univ Key Lab Chinese Med Extract P, Nanning 530200, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Hai Ke Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Pan, Zhenzhen,Kang, Xuejia,Zeng, Yuaner,et al. A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy[J]. POLYMER CHEMISTRY,2017,8(35):5275-5285.
APA	Pan, Zhenzhen.,Kang, Xuejia.,Zeng, Yuaner.,Zhang, Wenyuan.,Peng, Huige.,...&Huang, Yongzhuo.(2017).A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy.POLYMER CHEMISTRY,8(35),5275-5285.
MLA	Pan, Zhenzhen,et al."A mannosylated PEI-CPP hybrid for TRAIL gene targeting delivery for colorectal cancer therapy".POLYMER CHEMISTRY 8.35(2017):5275-5285.