Formation Mechanism and In Vitro Evaluation of Risperidone-Containing PLGA Microspheres Fabricated by Ultrafine Particle Processing System

doi:10.1016/j.xphs.2017.07.010

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	Formation Mechanism and In Vitro Evaluation of Risperidone-Containing PLGA Microspheres Fabricated by Ultrafine Particle Processing System
	Huang, Zhengwei 2; Chen, Xiaona 2; Fu, Han 2; Wen, Xinguo 2; Ma, Cheng 2; Zhang, Jiwen1 ; Wu, Chuanyu 3; Huang, Ying 2; Pan, Xin 2; Wu, Chuanbin 2
刊名	JOURNAL OF PHARMACEUTICAL SCIENCES
	2017-11
卷号	106 期号:11 页码:3363-3371
关键词	microspheres dissolution material science drug delivery systems controlled release
ISSN号	0022-3549
DOI	10.1016/j.xphs.2017.07.010
文献子类	Article
英文摘要	Ultrafine particle processing system (UPPS) was developed previously by our group to provide a new solution to microsphere fabrication. The UPPS was supposed to possess many featured advantages, but the microsphere formation mechanism during UPPS processing was still unknown. The objective of this study was to perform the formation mechanism investigation and in vitro evaluation on risperidone-containing poly(D,L-lactic-co-glycolic acid) microspheres (RIS-PLGA MS) fabricated by UPPS. Evaporation profile and viscosity of the PLGA-containing solutions were considered as the critical factors for the microsphere formation mechanism and were determined in present study. The formation mechanism of RIS-PLGA MS was put forward by semiquantitative analysis on the basis of the evaporation profile, viscosity, and scanning electron microscopy results. It was established that the evaporation profile and viscosity would have an impact on the evaporation velocity and PLGA molecular diffusion velocity during solidification process, resulting in different appearance of the microspheres. Furthermore, comprehensive in vitro evaluations of RIS-PLGA MS were conducted, including particle size distribution, micromeritics, morphology, drug loading, encapsulation efficiency, residual organic solvent, syringeability, and in vitro release behavior. The results revealed that RIS-PLGA MS was a promising candidate for intramuscular administration, and meanwhile UPPS was a qualified technology for microsphere production. (C) 2017 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
资助项目	111 project[B16047] ; Key Laboratory Foundation of Guangdong Province[2011A060901014] ; Special Funding Project for Research and Development of Applied Science and Technology of Guangdong Province[2015B020232010] ; Natural Science Foundation of Guangdong Province[2016A030312013] ; Public Research Platform for Production Technology of Novel Pharmaceutical Formulations, Science and Technology Foundation Guangzhou[201509030006] ; Innovative Scientific Research Team Introducing Project of Zhongshan City[2015-224]
WOS关键词	RELEASE ; SIZE ; VIVO ; MICROENCAPSULATION ; NANOPARTICLES ; FORMULATION ; NANOFIBERS ; SOLVENTS ; DELIVERY ; REACTOR
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	WILEY
WOS记录号	WOS:000417340400020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272416]
专题	药物制剂研究中心
通讯作者	Huang, Ying; Pan, Xin
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China; 3.Univ Surrey, Dept Chem & Proc Engn, Guildford GU2 7XH, Surrey, England
推荐引用方式 GB/T 7714	Huang, Zhengwei,Chen, Xiaona,Fu, Han,et al. Formation Mechanism and In Vitro Evaluation of Risperidone-Containing PLGA Microspheres Fabricated by Ultrafine Particle Processing System[J]. JOURNAL OF PHARMACEUTICAL SCIENCES,2017,106(11):3363-3371.
APA	Huang, Zhengwei.,Chen, Xiaona.,Fu, Han.,Wen, Xinguo.,Ma, Cheng.,...&Wu, Chuanbin.(2017).Formation Mechanism and In Vitro Evaluation of Risperidone-Containing PLGA Microspheres Fabricated by Ultrafine Particle Processing System.JOURNAL OF PHARMACEUTICAL SCIENCES,106(11),3363-3371.
MLA	Huang, Zhengwei,et al."Formation Mechanism and In Vitro Evaluation of Risperidone-Containing PLGA Microspheres Fabricated by Ultrafine Particle Processing System".JOURNAL OF PHARMACEUTICAL SCIENCES 106.11(2017):3363-3371.