Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation

doi:10.1016/j.apsb.2017.09.005

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation
	Li, Dongdong 1,2; Zhang, Meng 1; Xu, Fan 1,2; Chen, Yingzhi 1; Chen, Binfan 1; Chang, Ya 1,2; Zhong, Huihai 1,3; Jin, Hongyue 1; Huang, Yongzhuo1
刊名	ACTA PHARMACEUTICA SINICA B
	2018-01
卷号	8 期号:1 页码:74-84
关键词	Photothermal therapy Paclitaxel Combination therapy Gold nanorods Albumin Tumor-associated macrophage
ISSN号	2211-3835
DOI	10.1016/j.apsb.2017.09.005
文献子类	Article
英文摘要	Nanotechnology-based photothermal therapy has attracted great attention in the past decade. Nevertheless, photothermal therapy has some inherent drawbacks, such as the uneven heat production and limited laser penetration, often leading to insufficient treatment outcomes. Here, we developed a combination strategy to improve cancer therapy. The biomimetic albumin-modified gold nanorods (AuNRs) were prepared with incorporation of paclitaxel (PTX). This therapeutic system was characterized by several features. First, the albumin modification enhanced the biocompatibility and colloidal stability. Second, the surface-coated albumin promoted cellular uptake via the albumin-binding protein pathway. Third, PTX was incorporated via hydrophobic interaction between PTX and the albumin lipophilic domain. Fourth, the system can be used for combined photothermo-chemotherapy for yielding synergistic effects. The antitumor activity of the system was evaluated both in vitro and in vivo using the HCT116 colon cancer cell and tumor model. The combination therapy was found with an enhanced treatment efficiency and no obvious side effect. Most importantly, the thermal effect was also discovered with the ability to modulate the tumor microenvironments and suppress the macrophages polarization towards the M2 pro-tumor phenotype. It could be a mechanism for photothermal immunotherapy. The combination strategy and the system provide a potential method for cancer therapy. (C) 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
资助项目	National Basic Research Program of China (973 Program)[2014CB931900] ; National Basic Research Program of China (973 Program)[2013CB932503] ; NSFC, China[81373357] ; NSFC, China[81422048] ; NSFC, China[81673382] ; NSFC, China[81521005]
WOS关键词	TUMOR-ASSOCIATED MACROPHAGES ; CARBON NANOTUBES ; THERAPY ; CANCER ; NANOPARTICLES ; DOXORUBICIN ; NANOSHELLS ; COVERAGE ; ABLATION ; SILICA
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
WOS记录号	WOS:000426437100009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272324]
专题	药物制剂研究中心
通讯作者	Huang, Yongzhuo
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Univ Sci & Technol China, Nano Sci Tech Inst, Suzhou 215123, Peoples R China; 3.Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China
推荐引用方式 GB/T 7714	Li, Dongdong,Zhang, Meng,Xu, Fan,et al. Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation[J]. ACTA PHARMACEUTICA SINICA B,2018,8(1):74-84.
APA	Li, Dongdong.,Zhang, Meng.,Xu, Fan.,Chen, Yingzhi.,Chen, Binfan.,...&Huang, Yongzhuo.(2018).Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation.ACTA PHARMACEUTICA SINICA B,8(1),74-84.
MLA	Li, Dongdong,et al."Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation".ACTA PHARMACEUTICA SINICA B 8.1(2018):74-84.