Investigation of microstructures of freeze-dried orally disintegrating tablets by synchrotron radiation X-ray computed microtomography

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	Investigation of microstructures of freeze-dried orally disintegrating tablets by synchrotron radiation X-ray computed microtomography
	Liu Congbiao 3; Guo Zhen 1; Li Biao 2; Wang Jincan 2; Yin Xianzhen 1; Zhu Weifeng 3; Wang Liuyi 2; Zhang Jiwen3
刊名	Journal of China Pharmaceutical University
	2014
卷号	45 期号:1 页码:48-53
关键词	orally disintegrating tablets freeze powders by direct compression under low-temperature internal microstructures SR-muCT sub-structure
ISSN号	1000-5048
其他题名	基于同步辐射显微CT 技术研究冻干口腔崩解片的精细结构
文献子类	Article
英文摘要	Freeze-dried orally disintegrating tablets prepared by direct compression of the freezing powders under low-temperature were shown of different properties compared with molded freeze-dried orally disintegrating tablets. The aim of this study were to scan the interior microstructures of orally disintegrating tablets by synchrotron radiation X-ray computed microtomography (SR-muCT) and to reconstruct and characterize the three-dimensional structural models shown in the slice of the central section within tablets. By setting the threshold of gray value, the sub-structures of the orally disintegrating tablets were extracted and quantitatively analyzed by Image pro Analyzer 3D software. Disintegration time and frangibility of tablets were determined and compared to study the correlation between pharmaceutical properties and internal microstructures. The results indicated that internal microstructures of orally disintegrating tablets with different preparation processes and formulations varied markedly. Molded freeze-dried tablets had an integral net structure,while tablets made by direct compression had a loose clusters grainy one. The difference in the internal microstructures could well explain why freeze-dried orally disintegrating tablets made by direct compression would disintegrate fast in less than 5s. Different preparation processes and formulation could led to a variety of sub-structure sections,such as reticulation structure,compact enclo-sure,fragments and small particles,which was responsible for the macroscopic structural mechanical properties. In conclusion,the research showed that SR-muCT was powerful in providing insight into the internal microstructures, and the pharmaceutical properties of freeze-dried orally disintegrating tablets were directly related to the internalz microstructures.
资助项目	国家自然科学基金资助项目[00000000] ; 国家重大新药创制科技重大专项资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5081435
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269348]
专题	药物制剂研究中心分子影像中心（筹）
通讯作者	Zhang Jiwen
作者单位	1.Center for Drug Delivery System,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.; 2.Hainan Weikang Pharmaceutical (QianShan) Co.,Ltd., Anqing, Anhui 246300, China. 3.Key Laboratory of Modern Preparation Chinese Materia Medica of Ministry of Education,Jiangxi College of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, China.;
推荐引用方式 GB/T 7714	Liu Congbiao,Guo Zhen,Li Biao,et al. Investigation of microstructures of freeze-dried orally disintegrating tablets by synchrotron radiation X-ray computed microtomography[J]. Journal of China Pharmaceutical University,2014,45(1):48-53.
APA	Liu Congbiao.,Guo Zhen.,Li Biao.,Wang Jincan.,Yin Xianzhen.,...&Zhang Jiwen.(2014).Investigation of microstructures of freeze-dried orally disintegrating tablets by synchrotron radiation X-ray computed microtomography.Journal of China Pharmaceutical University,45(1),48-53.
MLA	Liu Congbiao,et al."Investigation of microstructures of freeze-dried orally disintegrating tablets by synchrotron radiation X-ray computed microtomography".Journal of China Pharmaceutical University 45.1(2014):48-53.