Three-dimensional structure of beads self-assembled by cyclodextrin using synchrotron radiation X-ray microcomputed tomography

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	Three-dimensional structure of beads self-assembled by cyclodextrin using synchrotron radiation X-ray microcomputed tomography
	DUAN Xiao-hui 1,2; WU Li 2; LI Xue 2; XU Jian 2; ZHANG Guo-qing 1,2; LI Hai-yan2 ; QIN Wei 2; YIN Xian-zhen 2; ZHANG Ji-wen1,2
刊名	Acta Pharmaceutica Sinica
	2018
卷号	53 期号:2 页码:291-296
关键词	beads beads cyclodextrin synchrotron radiation X-ray microcomputed tomography three-dimensional Pickering emulsion vitamin K_1
ISSN号	0513-4870
其他题名	同步辐射X射线显微成像研究环糊精自组装beads的三维结构
文献子类	Article
英文摘要	Beads,a novel drug delivery system self-assembled by cyclodextrins (CDs) and oil,has potential applications in the solidification of oil drugs and improving the bioavailability of lipid-soluble drugs. However,very few researches were dedicated to the mechanism of beads formation. In this study,three-dimensional structures of beads were visualized and investigated using synchrotron radiation X-ray microcomputed tomography(SR-muCT). The structural changes of beads attributed by drying process were analyzed and confirmed via visualization results of SR-muCT. Productively,it was proposed that Pickering emulsion droplets obtained during beads formation process were spatially localized orderly. Moreover,the effects of loading lipid soluble drug,namely,vitamin K_1,on the structural changes of beads were also analyzed. It is well known that the surface tension of oil phase could be changed by the addition of lipid soluble constituents. It was reasonable that the three-dimensional structure of beads might be altered during the drug loading of vitamin K1 into the beads. However,although the morphologies of beads were changed to some extent,the ordered Pickering emulsion droplets during the process of beads formation was successfully illustrated based on the SR-muCT results. Conclusively,according to the three-dimensional structural analysis of the beads,this study revealed the organized architecture for Pickering emulsion droplet assembly and beads formation in cyclodextrin semi-inclusion complex,which significantly complements the formation mechanism of beads,and provides a structural basis for the further study of beads.
资助项目	国家科技重大专项资助项目[00000000] ; 中国博士后科学基金资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:6161121
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269180]
专题	药物制剂研究中心
通讯作者	ZHANG Ji-wen
作者单位	1.School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China
推荐引用方式 GB/T 7714	DUAN Xiao-hui,WU Li,LI Xue,et al. Three-dimensional structure of beads self-assembled by cyclodextrin using synchrotron radiation X-ray microcomputed tomography[J]. Acta Pharmaceutica Sinica,2018,53(2):291-296.
APA	DUAN Xiao-hui.,WU Li.,LI Xue.,XU Jian.,ZHANG Guo-qing.,...&ZHANG Ji-wen.(2018).Three-dimensional structure of beads self-assembled by cyclodextrin using synchrotron radiation X-ray microcomputed tomography.Acta Pharmaceutica Sinica,53(2),291-296.
MLA	DUAN Xiao-hui,et al."Three-dimensional structure of beads self-assembled by cyclodextrin using synchrotron radiation X-ray microcomputed tomography".Acta Pharmaceutica Sinica 53.2(2018):291-296.