Reducing central serotonin in adulthood promotes hippocampal neurogenesis

doi:10.1038/srep20338

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 上海药物代谢研究中心

	Reducing central serotonin in adulthood promotes hippocampal neurogenesis
	Song, Ning-Ning 1,7; Jia, Yun-Fang 2,3; Zhang, Lei 1,7; Zhang, Qiong 1,7; Huang, Ying 1,7; Liu, Xiao-Zhen 7; Hu, Ling 1,7; Lan, Wei 1,4,7; Chen, Ling 1,7; Lesch, Klaus-Peter 5
刊名	SCIENTIFIC REPORTS
	2016-02-03
卷号	6
ISSN号	2045-2322
DOI	10.1038/srep20338
文献子类	Article
英文摘要	Chronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis. We used tamoxifen (TM)-induced Cre in Pet1-CreERT2 mice to either deplete central serotonergic (5-HTergic) neurons or inactivate 5-HT synthesis in adulthood and explore the role of central 5-HT in adult hippocampal neurogenesis. A dramatic increase in hippocampal neurogenesis is present in these two central 5-HT-deficient mice and it is largely prevented by administration of agonist for 5-HTR2c receptor. In addition, the survival of new-born neurons in the hippocampus is enhanced. Furthermore, the adult 5-HT-deficient mice showed reduced depression-like behaviors but enhanced contextual fear memory. These findings demonstrate that lowering central 5-HT function in adulthood can also enhance adult hippocampal neurogenesis, thus revealing a new aspect of central 5-HT in regulating adult neurogenesis.
资助项目	Ministry of Science and Technology of China[2013CB835100] ; Ministry of Science and Technology of China[2012CB966900] ; Ministry of Science and Technology of China[2011CB510000] ; Ministry of Science and Technology of China[2012AA022402] ; National Natural Science Foundation of China[81571332] ; National Natural Science Foundation of China[81221001] ; National Natural Science Foundation of China[31100788] ; National Natural Science Foundation of China[81200933] ; National Natural Science Foundation of China[81200692] ; National Natural Science Foundation of China[81101026] ; National Natural Science Foundation of China[91232724] ; Science and Technology Commission of Shanghai Municipality[12XD1404800] ; Fundamental Research Funds for the Central Universities[2013KJ049]
WOS关键词	SYNAPTIC PLASTICITY ; CHRONIC FLUOXETINE ; BRAIN-SEROTONIN ; DEFICIENT MICE ; DENTATE GYRUS ; ANTIDEPRESSANT ; EXERCISE ; CELLS ; TRANSPORTER ; EXPRESSION
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000369792100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276152]
专题	上海药物代谢研究中心
通讯作者	Xu, Lin; Ding, Yu-Qiang
作者单位	1.Tongji Univ, Sch Med, Dept Anat & Neurobiol, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China; 2.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China; 3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China; 4.Guangxi Med Univ, Dept Human Anat, Nanning, Guangxi, Peoples R China; 5.Univ Wurzburg, Dept Psychiat & Psychotherapy, Div Mol Psychiat, D-97070 Wurzburg, Germany; 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 7.Tongji Univ, East Hosp, Key Lab Arrhythmias, Minist Educ,Sch Med, Shanghai 200092, Peoples R China;
推荐引用方式 GB/T 7714	Song, Ning-Ning,Jia, Yun-Fang,Zhang, Lei,et al. Reducing central serotonin in adulthood promotes hippocampal neurogenesis[J]. SCIENTIFIC REPORTS,2016,6.
APA	Song, Ning-Ning.,Jia, Yun-Fang.,Zhang, Lei.,Zhang, Qiong.,Huang, Ying.,...&Ding, Yu-Qiang.(2016).Reducing central serotonin in adulthood promotes hippocampal neurogenesis.SCIENTIFIC REPORTS,6.
MLA	Song, Ning-Ning,et al."Reducing central serotonin in adulthood promotes hippocampal neurogenesis".SCIENTIFIC REPORTS 6(2016).