Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis

doi:10.1002/jcb.23450

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis
	Wu, Jinwei; Sun, Peng; Zhang, Xiaodong; Liu, Hong; Jiang, Hualiang; Zhu, Weiliang; Wang, Heyao
刊名	JOURNAL OF CELLULAR BIOCHEMISTRY
	2012-04
卷号	113 期号:4 页码:1152-1158
关键词	GPR40 ANTAGONIST MIN6 ss CELLS PALMITATE ENDOPLASMIC RETICULUM STRESS APOPTOSIS
ISSN号	0730-2312
DOI	10.1002/jcb.23450
文献子类	Article
英文摘要	Chronic exposure to elevated concentration of free fatty acids (FFA) has been verified to induce endoplasmic reticulum (ER) stress, which leads to pancreatic beta-cell apoptosis. As one of the medium and long chain FFA receptors, GPR40 is highly expressed in pancreatic beta cells, mediates both acute and chronic effects of FFA on beta-cell function, but the role of GPR40 in FFA-induced beta-cell apoptosis remains unclear. In this study, we investigated the possible effects of GPR40 in palmitate-induced MIN6 beta-cell apoptosis, and found that DC260126, a novel small molecular antagonist of GPR40, could protect MIN6 beta cells from palmitate-induced ER stress and apoptosis. Similar results were observed in GPR40-deficient MIN6 cells, indicating that palmitate-induced beta-cell apoptosis is at least partially dependent on ER stress pathway via GRP40. J. Cell. Biochem. 113: 11521158, 2012. (c) 2011 Wiley Periodicals, Inc.
资助项目	National Natural Science Foundation of China[81073681] ; National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2009ZX09301-001] ; National High Technology Research and Development Program of China (863 Program)[2007AA02Z301] ; Shanghai Science and Technology Innovation Program[08431900800]
WOS关键词	ENDOPLASMIC-RETICULUM STRESS ; FATTY-ACID RECEPTOR ; INSULIN-SECRETION ; DYSFUNCTION ; MECHANISMS ; DEATH ; ANTAGONIST ; RESISTANCE ; INCREASE ; IMPROVES
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	WILEY
WOS记录号	WOS:000300719000008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278138]
专题	药理学第三研究室
通讯作者	Wang, Heyao
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wu, Jinwei,Sun, Peng,Zhang, Xiaodong,et al. Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2012,113(4):1152-1158.
APA	Wu, Jinwei.,Sun, Peng.,Zhang, Xiaodong.,Liu, Hong.,Jiang, Hualiang.,...&Wang, Heyao.(2012).Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis.JOURNAL OF CELLULAR BIOCHEMISTRY,113(4),1152-1158.
MLA	Wu, Jinwei,et al."Inhibition of GPR40 protects MIN6 beta cells from palmitate-induced ER stress and apoptosis".JOURNAL OF CELLULAR BIOCHEMISTRY 113.4(2012):1152-1158.