Angoline: A selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum

doi:10.1016/j.phymed.2014.04.001

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	Angoline: A selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum
	Liu, Jiawei 1; Zhang, Qing2 ; Ye, Yushan 1; Li, Wuguo 1; Qiu, Junxin 1; Liu, Jingli 2; Zhan, Ruoting 1; Chen, Weiwen 1; Yu, Qiang2
刊名	PHYTOMEDICINE
	2014-07
卷号	21 期号:8-9 页码:1088-1091
关键词	STAT3 signaling pathway Inhibitor Zanthoxylum nitidum Angoline
ISSN号	0944-7113
DOI	10.1016/j.phymed.2014.04.001
文献子类	Article
英文摘要	STAT3 signaling pathway is an important target for human cancer therapy. Thus, the identification of small-molecules that target STAT3 signaling will be of great interests in the development of anticancer agents. The aim of this study was to identify novel inhibitors of STAT3 pathway from the roots of Zanthoxylum nitidum (Roxb.) DC. The bioassay-guided fractionation of MeOH extract of Z. nitidum using a STAT3-responsive gene reporter assay led to the isolation of angoline (1) as a potent and selective inhibitor of the STAT3 signaling pathway (IC50 = 11.56 mu M). Angoline inhibited STAT3 phosphorylation and its target gene expression and consequently induced growth inhibition of human cancer cells with constitutively activated STAT3 (IC50 = 3.14-4.72 mu M). This work provided a novel lead for the development of anti-cancer agents targeting the STAT3 signaling pathway. (C) 2014 Elsevier GmbH. All rights reserved.
资助项目	China National Natural Science Foundation[81373432] ; Special Project on the Integration of Industry, Education and Research of Guangdong Province[2009B090300202] ; Guangzhuo Science and Technology Program Grant[132000207] ; 211 Project Grant of Guangzhou University of Chinese Medicine[2009319]
WOS关键词	BENZOPHENANTHRIDINE ALKALOIDS ; CONSTITUTIVE ACTIVATION ; CARCINOMA CELLS ; STAT3 ; APOPTOSIS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	ELSEVIER GMBH, URBAN & FISCHER VERLAG
WOS记录号	WOS:000337932000011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277013]
专题	药理学第一研究室
通讯作者	Liu, Jingli
作者单位	1.Guangzhou Univ Chinese Med, Res Ctr Med Plants Resource Sci & Engn, Minist Educ, Key Lab Chinese Med Plants Resource Lingnan, Guangzhou 510006, Guangdong, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jiawei,Zhang, Qing,Ye, Yushan,et al. Angoline: A selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum[J]. PHYTOMEDICINE,2014,21(8-9):1088-1091.
APA	Liu, Jiawei.,Zhang, Qing.,Ye, Yushan.,Li, Wuguo.,Qiu, Junxin.,...&Yu, Qiang.(2014).Angoline: A selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum.PHYTOMEDICINE,21(8-9),1088-1091.
MLA	Liu, Jiawei,et al."Angoline: A selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum".PHYTOMEDICINE 21.8-9(2014):1088-1091.