Recent developments in antivirals against hepatitis B virus

doi:10.1016/j.virusres.2015.12.014

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Recent developments in antivirals against hepatitis B virus
	Wang, Ya-Juan; Yang, Li; Zuo, Jian-Ping
刊名	VIRUS RESEARCH
	2016-02-02
卷号	213 页码:205-213
关键词	Hepatitis B Antiviral therapy Inhibitory drugs Host immune regulators
ISSN号	0168-1702
DOI	10.1016/j.virusres.2015.12.014
文献子类	Review
英文摘要	Chronic hepatitis B virus (HBV) infection (CHB) is a major cause of cirrhosis and hepatocellular carcinoma (HCC). Although the availability of HBV vaccines effectively reduces the incidence of HBV infection, the healthcare burden from CHB remains high. Several antiviral agents, such as (pegylated-) interferon-alpha and nucleos(t)ide analogs are approved by US FDA for chronic HBV infection management. Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) have been recommended as the first-line anti-HBV drugs for excellent viral suppression with a low risk of antiviral resistance, but the cost and need for essentially life-long treatment are considerable challenges. And none of these current treatments can eradicate the intracellular virus. Given these issues, there is still an unmet medical need for an efficient HBV cure. We summarize here the key developments of antivirals against hepatitis B virus, including HBV replication cycle inhibitors and host immune regulators. (C) 2015 Elsevier B.V. All rights reserved.
WOS关键词	COTRANSPORTING POLYPEPTIDE NTCP ; IMMUNOSUPPRESSIVE DRUG-THERAPY ; LARGE ENVELOPE PROTEIN ; IN-VIVO ; LIFE-CYCLE ; RECEPTOR RECOGNITION ; MEMBRANE TRANSPORTER ; EFFECTOR NUCLEASES ; CLINICAL-PRACTICE ; HBV REPLICATION
WOS研究方向	Virology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000371840600023
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276153]
专题	药理学第一研究室
通讯作者	Yang, Li; Zuo, Jian-Ping
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Zuchongzhi Rd 555, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ya-Juan,Yang, Li,Zuo, Jian-Ping. Recent developments in antivirals against hepatitis B virus[J]. VIRUS RESEARCH,2016,213:205-213.
APA	Wang, Ya-Juan,Yang, Li,&Zuo, Jian-Ping.(2016).Recent developments in antivirals against hepatitis B virus.VIRUS RESEARCH,213,205-213.
MLA	Wang, Ya-Juan,et al."Recent developments in antivirals against hepatitis B virus".VIRUS RESEARCH 213(2016):205-213.