Determination of Dexibuprofen and Levocetirizine in Beagle Dog Plasma by LC-MS/MS with Positive/Negative Ion-switching Electrospray Ionization

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	Determination of Dexibuprofen and Levocetirizine in Beagle Dog Plasma by LC-MS/MS with Positive/Negative Ion-switching Electrospray Ionization
	Niu Xiaoying 1; Xiong Xiaoyun 2; Zhang Yifan3 ; Su Jianying 2; Zhong Dafang1
刊名	Chinese Journal of Pharmaceuticals
	2012
卷号	43 期号:4 页码:286-291
关键词	dexibuprofen levocetirizine LC-MS/MS determination
ISSN号	1001-8255
其他题名	犬血浆中右旋布洛芬和左西替利嗪的正负离子切换LC-MS/MS法测定
文献子类	Article
英文摘要	A LC-MS/MS method was established for the determination of dexibuprofen and levocetirizine in Beagle dog plasma.A C18 column was used with the mobile phase of acetonitrile-methano1-5 mmol/L ammonium acetate solution(25︰56.25︰18.75).A tandem mass spectrometric detection was conducted using multiple reaction monitoring(MRM) under the positive/negative ionization switching mode.The calibration curves of dexibuprofen and levocetirizine were linear in the ranges of 0.2-100 mug/ml and 0.008-4 mug/ml.The intra-and inter-day RSDs were less than 8.7% and the extraction recoveries were over 80.9%.
WOS研究方向	Pharmacology & Pharmacy ; Chemistry (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4525501
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267845]
专题	上海药物代谢研究中心
通讯作者	Zhong Dafang
作者单位	1.Soochow University, Suzhou, Jiangsu 215123, China.; 2.Xian Lijun Pharmaceutical Co.,Ltd., Xian, 710077.; 3.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Niu Xiaoying,Xiong Xiaoyun,Zhang Yifan,et al. Determination of Dexibuprofen and Levocetirizine in Beagle Dog Plasma by LC-MS/MS with Positive/Negative Ion-switching Electrospray Ionization[J]. Chinese Journal of Pharmaceuticals,2012,43(4):286-291.
APA	Niu Xiaoying,Xiong Xiaoyun,Zhang Yifan,Su Jianying,&Zhong Dafang.(2012).Determination of Dexibuprofen and Levocetirizine in Beagle Dog Plasma by LC-MS/MS with Positive/Negative Ion-switching Electrospray Ionization.Chinese Journal of Pharmaceuticals,43(4),286-291.
MLA	Niu Xiaoying,et al."Determination of Dexibuprofen and Levocetirizine in Beagle Dog Plasma by LC-MS/MS with Positive/Negative Ion-switching Electrospray Ionization".Chinese Journal of Pharmaceuticals 43.4(2012):286-291.