Copper mediated C-H amination with oximes: en route to primary anilines

doi:10.1039/c8sc01256c

	Copper mediated C-H amination with oximes: en route to primary anilines
	Xu, Lin-Lin 2; Wang, Xing 3; Ma, Biao 3; Yin, Ming-Xing 3; Lin, Hai-Xia 2; Dai, Hui-Xiong3 ; Yu, Jin-Quan 1
刊名	CHEMICAL SCIENCE
	2018-06-21
卷号	9 期号:23 页码:5160-5164
ISSN号	2041-6520
DOI	10.1039/c8sc01256c
文献子类	Article
英文摘要	Here we report an efficient Cu(I)-mediated C-H amination reaction with oximes as amino donors to introduce NH2 groups directly. Various strongly coordinating heterocycles including quinoline, pyrimidine, pyrazine, pyrazole and triazole were tolerated well. The potential utility was further demonstrated in a late-stage modification of telmisartan (an antagonist for the angiotensin II receptor).
资助项目	Shanghai Institute of Materia Medica, Chinese Academy of Sciences[NSFC-21472211] ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences[NSFC-21772211] ; Youth Innovation Promotion Association CAS[2014229] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; NSF under the CCI Center for Selective C-H Functionalization[CHE-1205646]
WOS关键词	CARBON-HYDROGEN BONDS ; CATALYZED SYNTHESIS ; ROOM-TEMPERATURE ; AQUEOUS AMMONIA ; PRIMARY AMINES ; HETEROCYCLES ; ACTIVATION ; ARENES ; ACIDS ; FUNCTIONALIZATION
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000435350200004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279699]
专题	药物化学研究室
通讯作者	Dai, Hui-Xiong
作者单位	1.Scripps Res Inst, Dept Chem, 10550N Torrey Pines Rd, La Jolla, CA 92037 USA 2.Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China; 3.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Xu, Lin-Lin,Wang, Xing,Ma, Biao,et al. Copper mediated C-H amination with oximes: en route to primary anilines[J]. CHEMICAL SCIENCE,2018,9(23):5160-5164.
APA	Xu, Lin-Lin.,Wang, Xing.,Ma, Biao.,Yin, Ming-Xing.,Lin, Hai-Xia.,...&Yu, Jin-Quan.(2018).Copper mediated C-H amination with oximes: en route to primary anilines.CHEMICAL SCIENCE,9(23),5160-5164.
MLA	Xu, Lin-Lin,et al."Copper mediated C-H amination with oximes: en route to primary anilines".CHEMICAL SCIENCE 9.23(2018):5160-5164.